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pombase / fypo

Fission Yeast Phenotype Ontology
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PMID:26205977 #2741

Closed Antonialock closed 8 years ago

Antonialock commented 8 years ago

normal frequency of knob containing nuclei decreased frequency of knob containing nuclei

mah11 commented 8 years ago

How should we define these "knobs"?

And are these population phenotypes? Sounds like it from the names ...

Antonialock commented 8 years ago

d'oh, tI emant to include more information.

So knobs are highly condensed chromatin bodies formed from subtelomeric (ST-) heterochromatin. Knobs form on chromosomes 1 and 2 only from what is known so far.

I'm not sure if it is best to do it at a population level or at a cellular level. They measure it at the population level (this cell has a knob, this one doesn't). but I think it would also work at the cellular level (decreased subtelomeric chromatin condensation? synonymous to decreased knob formation?).

mah11 commented 8 years ago

OK, I've done them as cell-level process terms:

normal subtelomeric chromatin knob formation FYPO:0005527 decreased subtelomeric chromatin knob formation FYPO:0005528

mah11 commented 8 years ago

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