NTR: decreased mitotic spindle pole body oscillation

[ValWood]

partner term of

FYPO:0005349 Ontology fission_yeast_phenotype Term name increased mitotic spindle pole body movement Definition A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the mitotic spindle pole body (SPB) moves rapidly back and forth over a large area. Normally, the SPB may move slightly but such movement is restricted to a small space.

Perhaps revise the definition to A cellular process phenotype observed in _mitotic prophase_*

(I wonder if the synonym 'oscillation' is a better name than movement, because there is other movement apart from the 'rapid oscillation' described here?)

[mah11]

I looked at the ticket for FYPO:0005349 and didn't see any reason not to use "oscillation" in the name, so no problem to swap name & synonym.

Perhaps revise the definition to A cellular process phenotype observed in mitotic prophase

No, the "observed in the vegetative growth phase of the life cycle" bit is the standard boilerplate for all "vegetative" term defs. I'll put something about prophase elsewhere in the def.

[ValWood]

OK

[mah11]

Looking at this again ... the FYPO:0005349 def implies that oscillatory movement isn't really a normal thing for the mitotic SPB to do. Was that incorrect? If oscillation can be decreased by a mutant, there must be some oscillation happening in wild type, and if that's true we ought to rephrase the FYPO:0005349 def to just say "more than normal".

[ValWood]

It appears to be normal, but I hadn't come across it in mitosis before this paper (or at least it hadn't stuck...)

PMID:16394105 Sister Chromatid Oscillation during Prometaphase Is Less Dynamic in the atb2-983 Mutant Independent of Mal3 Dysfunction It is shown that during mid-mitosis, fission yeast kineto- chores display, like animal cells, back-and-forth oscillation between the two poles, which is likely to correspond to the prometaphase state (Saitoh et al., 1997; Garcia et al., 2002b).

[mah11]

That seems to be about kinetochores moving between SPBs, not the SPB itself moving ...?

[mah11]

for now, I've swapped the name and "oscillation" synonym FYPO:0005349

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[ValWood]

Durr yes sorry kinetochore oscillation... that makes more sense!

[ValWood]

Although: PMID:19001497 and a strong reduction in SPB oscillations, which probably reflects reduced interactions between cytoplasmic MTs and the SPB (Fig. 1E; supplementary material Movies 2-4).

[mah11]

new term mitotic spindle pole body oscillation FYPO:0005691

edited def FYPO:0005349

I think that's everything for this one ...

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