variable size at division

[ValWood]

FYPO:0007474 variable cell size at division

Defined A cell population phenotype in which cells in a population do not divide at a uniform size. Cells in one population may be larger or smaller than normal (i.e. compared to wild-type cells under the same conditions).

Jacky suggested variable cell length at entry into mitosis followed by equal cell division A cell population phenotype in which cells in a population do not divide at a uniform size. Cells undergo equal cell division but the cell length at which they initiate mitosis within one population may be longer or shorter than normal (i.e. compared to wild-type cells under the same conditions).

because a mixed population of cells could also be caused by

abnormal cell division, large and small daughter cells (FYPO:0002029)

@mah11 I will let you figure the solution because one is a cell phenotype and one is a population phenotype. We may want to be more explicit about FYPO:0007474 rather than creating a descendant term?

[ValWood]

@JackyVH I see you also requested another descendant of FYPO:0007474

abnormal cell size homeostasis = cells that divide at an abnormal size fail to correct in the following cell cycle

[ValWood]

so FYPO:0007474 variable cell size at division is 'less accurate monitoring of cell size"

but inability to correct cell-size deviations, is "loss of homeostasis"

[ValWood]

@JackyVH should we have some mutants annotated as "variable cell size at division" from Navarro and Nurse?

[JackyVH]

Let me check for tomorrow

[mah11]

Add to FYPO:0007474 text def to specify that all cells in the population divide "equally", i.e. daughter cells are the same size as each other.

[mah11]

cell size homeostasis (for pombe) = a cell that has come into existence at a wild-type size itelf divides at wild-type size

[mah11]

some mutants that would be annotated to FYPO:0007474 do, and others do not, subsequently divide at normal size

It's a bit of a cheat to represent them as subclasses of FYPO:0007474, because it's a little awkward putting them in as population phenotypes, but we'll bumble along with it.

[mah11]

OK, I futzed with the FYPO:0007474 definition, and added these:

variable cell size at division with subsequent division at normal size FYPO:0007659 variable cell size at division with subsequent division at abnormal size FYPO:0007660

Let me know if I've got anything wrong in the definitions, or if the names, defs, synonyms, etc. can be improved at all. (My brain is melting ...)

[ValWood]

PMID:33419777