NTR for PMID:37200372

[manulera]

decreased vegetative cell population growth after short incubation in hydroxyurea normal vegetative cell population growth after short incubation in hydroxyurea

[ValWood]

I wonder if we should avoid this because it's really a condition rather than a phenotype, and we have tried to exclude aspects of the expreiemtnal set up which are independent of the genotype/construct from FYPO so far.

In the past if we had to, we have done this:

So perhaps a condition for "transient exposure" which could be used generally would be sufficient?

[manulera]

Hi @ValWood, I agree that in the future we should find a solution to split phenotype and conditions. But in terms of our current way of doing things, I don't see how this is different from "sensitive to HU", which is "decreased vegetative cell population growth", with condition "+ HU".

[manulera]

I added a FYECO term as well. What should I do? Should I remove the FYPO terms?

[Term]
id: FYECO:0000434
name: transient hydroxyurea treatment
def: "Experiments were performed on normal medium after a short incubation in medium containing hydroxyurea." [PomBase:mlr]
xref: PMID:37200372
is_a: FYECO:0000109 ! grouping excess
synonym: "acute hydroxyurea treatment" BROAD [PMID:37200372]
created_by: mlr
creation_date: 2023-07-10T13:00:00Z

[ValWood]

I take your point. It feels a bit different but maybe only because it was convenient. Let's not worry about it for now. I think if it is confined to the population phenotypes (which are quite different anyway) it's OK.

[manulera]

I will do both (FYECO + FYPO term). At some point in the future, hopefully it should be doable to correct the annotations from the logical definitions.