search

pombase / fypo

Fission Yeast Phenotype Ontology
Creative Commons Attribution 4.0 International
15 stars 6 forks source link

chromosomal rearrangements #443

Closed fypoadmin closed 9 years ago

fypoadmin commented 11 years ago
  1. increased rate/occurrence of gross chromosomal rearrangements I think the 'gross' is meant to distinguish it from stuff like gene conversions. This can probably be a child of abnormal chromatin organisation? possibly also DNA repair? (I assume these things only happen after a DSB and the cell trying to repair its chromosomes? I'm not certain about this though - perhaps the chromosomes can arrange themselves "spontaneously" during irradiation or other damaging events?).

with children:

  1. increased rate/occurrence of chromosomal translocation this is where a part of a chromosome is replaced with a part of another non-homologous chromosome
  2. increased rate/occurrence of isochromosome formation this is where one arm is lost and the other arm is duplicated in its place

with child:

  1. increased rate/occurrence of isochromosome formation with preferential breaking in the imr region let me know if this term is too specific (I guess the line has to be drawn somewhere. I have already left out some other detail, for instance, the minichromsome is derived from chromosome 3, I'm not sure if that should be mentioned? The chromosomes are a bit different…). When WT cells acquire isochromosome, the break-point is formed half the time in the imr region and half the time in the otr-irc region. In this mutant, the majority (14 repeats out of 15) occurred in the imr region.

Original comment by: Antonialock

fypoadmin commented 11 years ago

increased gross chromosomal rearrangement FYPO:0001740 increased chromosomal translocation FYPO:0001741 increased isochromosome formation FYPO:0001742 increased isochromosome formation with preferential breakage in the imr region FYPO:0001743

I've just put FYPO:0001740 under abnormal chromosome organization for now; I suspect there may be a connection to DNA repair but I wouldn't like to stick my neck out and say repair is abnormal (could be normal repair following increased breakage, perhaps).

I've defined them as increased occurrence, since I think of "rate" as how fast something happens and I don't think they addressed that (I wouldn't blame them if they don't care ;) ).

Original comment by: mah11

fypoadmin commented 11 years ago

Original comment by: mah11