PMID:38448160

[PCarme]

New term (based on author suggestion) : equational sister chromatid segregation during achiasmatic meiosis I A cellular process phenotype in which sister kinetochores become separated during the first meiotic nuclear division, and sister chromatids subsequently separate to result in equational segregation, only visible in the absence of chiasmata. Equational sister chromatid separation is caused by bi-orientated attachment of sister chromatids.

New term : increased protein localization to chromatin at centromere central core during meiotic prophase I A cell phenotype in which the localization of a protein to chromatin at the centromere central core is increased during prophase of the first meiotic nuclear division.

New term : increased protein localization to pericentric heterochromatin during meiotic prophase I A cell phenotype in which the localization of a protein to pericentric heterochromatin is increased during prophase of the first meiotic nuclear division.

New term : normal protein localization to pericentric heterochromatin during meiotic prophase I A cell phenotype in which the localization of a protein to pericentric heterochromatin is normal during prophase of the first meiotic nuclear division.

[PCarme]

I think the main difference between this term and the one Yoshi suggests is the specification that their phenotype is only apparent during an achiasmatic meiosis I. In fact, in the paper, this phenotype is only visible in cells that carry a mutation that abolishes the formation of chiasmata.

[ValWood]

FYPO:0005634 sister kinetochore dissociation in meiotic metaphase I with equational sister chromatid segregation in meiosis I

Decision Add equational sister chromatid segregation during achiasmatic meiosis I as a narrow synonym

Move rec12 (which removed chismata) into the foreground. This is more in line with a genetic interaction, because the phenotype is only visible when rec12 is mutated.

[ValWood]

I added A cellular process phenotype in which sister kinetochores become separated during the first meiotic nuclear division, and sister chromatids subsequently separate to result in equational segregation, only visible in the absence of chiasmata. Equational sister chromatid separation is caused by bi-orientated attachment of sister chromatids.

It contains information about the genotype which isn't really allowed. We decided to keep it for now as this enables to capture a GI which would not be possible because it is only possible to capture interactions between 2 genes. This way rec12delta is in the background. I'm not very comfortable with this but can't think of a better way right now.

[ValWood]

Still needs

Unequal sister chromatid segregation in meiosis II after reductional segregation in meiosis I.

also a problem

remove parent "abnormal meiotic sister chromatid segregation" from unequal meiotic sister chromatid segregation in meiosis | -

[PCarme]

Unequal sister chromatid segregation in meiosis II after reductional segregation in meiosis I.

Is it not the same as "sister kinetochore dissociation in meiotic metaphase I, normal chromosome segregation in meiosis I, and unequal sister chromatid segregation in meiosis II" (FYPO:0005633) ?

[ValWood]

Yes it is!

at least if "sister kinetochore dissociation in meiotic metaphase I" is always present in this phenotype? I'm not sure if it is the case but we can always add a parent later if not.

[PCarme]

The session went through with Yoshinori's recent feedback. I think we can close this one.