search

pombase / fypo

Fission Yeast Phenotype Ontology
Creative Commons Attribution 4.0 International
14 stars 6 forks source link

PMID:37553386 #4521

Closed PCarme closed 5 months ago

PCarme commented 5 months ago

New term : decreased reticulophagy during vegetative growth A cellular process phenotype observed in the vegetative growth phase of the life cycle in which autophagic degradation of the endoplasmic reticulum occurs to a lower extent than normal.

ValWood commented 5 months ago

Is this the correct term? decreased reticulophagy during cellular response to endoplasmic reticulum stress

I assume reticulophagy is always in response to ER stress? although perhaps not... I will add

PCarme commented 5 months ago

ER-phagy happens in cells in stationary phase, in nitrogen starved cells, in the UPR... The way I see it, ER stress designates the UPR-associated pathway specifically, although I might be wrong...

ValWood commented 5 months ago

OK, of course, that makes sense. I already added the new term (the release is nearly ready), but the

"decreased reticulophagy during cellular response to endoplasmic reticulum stress"

is currently defined as a vegetative term (hence I made it a child of the new term), but this seems wrong.

I'll take a look at the annotation and see if we need to refine "decreased reticulophagy during cellular response to endoplasmic reticulum stress"

ValWood commented 5 months ago

OK, the exisitng annotations to "decreased reticulophagy during cellular response to endoplasmic reticulum stress" are OK, and are during vegetative growth.

so it is OK as a descendant of the new term New term : decreased reticulophagy during vegetative growth

we can add more new terms as required.