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pombase / mitochondrion

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mitochondrial disulfide relay system (GO:0160203) #8

Open ValWood opened 2 weeks ago

ValWood commented 2 weeks ago

Aif1 currently "conserved unknown" (I can't find the evidence for this?) erv1 (only has protein folding) (Asked SGD to make more specific for ISS)

https://www.uniprot.org/uniprotkb/O95831/entry is over-annotated

hattrill commented 22 hours ago

For D.mel we have the MITOCHONDRIAL DISULFIDE RELAY SYTEM gene group:

FBgn0031392 Apoptosis inducing factor AIF FBgn0031068 Augmenter of liver regeneration Alr FBgn0260468 Mitochondrial intermembrane space Import and Assembly 40 Mia40

Curated from PMID: 32936885 "AIF is a component of the MIA disulfide relay-dependent import pathway (Meyer et al., 2015; Hangen et al., 2015; Modjtahedi and Kroemer, 2016). Other primary components of this pathway are the oxidoreductase Mia40/CHCHD4 and the sulfhydryl oxidase Erv1/ALR (Hell, 2008). Drosophila orthologues of Mia40 and Erv1 are CG7950 and CG12534"

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Fly | Human | cerevisiae | pombe -- | -- | -- | -- Alr | GFER | ERV1 | erv1 AIF | AIFM1 | AIF1 | aif1 Mia40 | CHCHD4 | MIA40 | tim40