Antonialock
commented
5 years ago wrong tracker, transfer button not working
Closed Antonialock closed 5 years ago
Antonialock
commented
5 years ago wrong tracker, transfer button not working
we had a few tickets and the annotation is a bit messy so checking and improving it.
need to add to this story....
1) TRANSCRIPTIONAL REGULATION
HIGH IRON
Fep1 transcriptionally negatively regulates php4 and iron acquisition genes (e.g. frp1, fio1, fip1, str1,2,3) Tup11/12 are corepressors Grx4 bound to iron sulphur cluster activates fep1
Grx4 bound to iron sulphur cluster binds php4, and promotes its nuclear export
Php2/3/5 transcriptionally positively regulates iron requiring genes
LOW IRON
when grx4 is not bound to iron php4 is allowed to interact with php2/3/5. Fe using genes are no longer expressed
when grx4 is not bound to iron fep1 can't bind DNA and Fe transport genes are activated
2) IRON UPTAKE
REDUCTIVE SYSTEM Frp1 reduces ferric iron to ferrous Fio1/fip1 transports the ferrous iron across PM into cell
NONREDUCTIVE SYSTEM Siderophore ferrichrome biosynthesis: Sib2-SPBC17G9.06c-sib1
Siderophore uptake: str1 Ferrixomaine B iron: str2 ?: str3
Shu1 imports heme.
3) IRON STORAGE
In high iron, iron is stored in vacuoles (possibly as ferrichromes)
Pcl1: in high iron, pal1 transports Fe from cytosol into vacuole Abc3: In low iron abc3 transports iron from vacuole to cytosol
GO TERMS:
negative regulation of transcription from RNA polymerase II promoter in response to iron ion starvation Php4 Tup11 add Tup12 add
Cellular iron ion homeostasis Grx4 yes Which ones other?
positive regulation of transcription from RNA polymerase II promoter in response to iron Php2 Php3 Php5
Reductive iron assimilation Fio1 fip1 Frp1