gnomAD genomes + exomes MAF test is applied to Cat. 1 Dominant Variants during MOI test
they still have an exception permitting low read depths
they also have an exception for recessive MOI (comp-Het or Hom) - this can be removed as well, but the main focus here is tidying up erroneous monoallelic variants
If this variant only satisfied an 'Autosomal Dominant' MOI
This takes the "does not qualify as any Recessive or X-Linked MOI" exclusions in #304 and reverses them - "we're only flagging Cat.1 non-de Novo variants with ambiguous MOIs, where we only satisfied an Autosomal Dominant MOI"
Misc
Includes a few QOL fixes to the 'forbidden gene' checker required for the retrospective analysis. Now PanelApp activities endpoint queries are O(panels) instead of O(panels * timepoints)
DocString formatting changes - non functional, but a more consistent look
Fixes
Proposed Changes
This takes the "does not qualify as any Recessive or X-Linked MOI" exclusions in #304 and reverses them - "we're only flagging Cat.1 non-de Novo variants with ambiguous MOIs, where we only satisfied an Autosomal Dominant MOI"
Misc
Checklist