search

privefl / bigsnpr

R package for the analysis of massive SNP arrays.
https://privefl.github.io/bigsnpr/
183 stars 43 forks source link

negative heritablity result #461

Closed DUAN-GAO closed 8 months ago

DUAN-GAO commented 8 months ago

Sir,Madam Hello, thanks for the remarkable algorithm developed. I used HapMap3 LD blocks and one GWAS summary statistics file I downloaded from GWAS summary official website. I followed your script all along, I succeeded halfway without any error, however, the h2 I estimated is negative, not positive, something like -0.5803676. Could u help. Many thanks.

privefl commented 8 months ago

Could you provide the 4 numbers you get from LDSC? Have you verified the distribution of chi-squared statistics?

DUAN-GAO commented 8 months ago

Bonjour, Monsieur Merci de votre réponse rapide : )

La question a été résolue en changeant les fichiers de GWAS summary. Je voudrais savoir comment interpréter le score, parce que j'ai obtenu des scores positifs et négatifs allant de -99 à 30. Et ne soyez pas surpris de voir que je parle français, car j'ai étudié en Belgique.

privefl commented 8 months ago

Please write in English, so that others can benefit from our discussion.

Also, please open a new issue if you have another question.