Can I use univLogReg to test additive effects?

privefl / bigstatsr

R package for statistical tools with big matrices stored on disk.

https://privefl.github.io/bigstatsr/

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Closed garyzhubc closed 3 months ago

garyzhubc commented 3 months ago

Can I use univLogReg or any functions here to test additive effects of several genotypes?

privefl commented 3 months ago

univLogReg() can be used to perform a GWAS for a binary trait, if that's your question.

If you want to test for joint effects, you need to go for polygenic scores or Mendelian randomization.