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I output the text of the records with inconsistent text columns and tag columns, and find that they do not correctly treat a row as an example, such as:‘plsr is a multivariate regression technique commonly applied to analyze relationships between signaling or transcriptional data and cellular behavior . o o o o o o o o o o o o o o o o o o o o o 23593923 functional conservation and structural diversification of silk sericins in two moth species . o o o o o o o o o o o o o 23593923 sericins are hydrophilic structural proteins produced by caterpillars in the middle section of silk glands and are layered over fibroin proteins secreted in the posterior section . o o o o o o o o o o o o o o o o o o o o o o o o o o o 23593923 in the process of spinning , fibroins form strong solid filaments , while sericins seal the pair of filaments into a single fiber and glue the fiber into a cocoon . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23593923 galleria mellonella and the previously examined bombyx mori harbor three sericin genes that encode proteins containing long repetitive regions . o o o o o o o o o o o o o o o o o o o o 23593923 galleria sericin genes are similar to each other and the protein repeats are built from short and extremely serine - rich motifs , while bombyx sericin genes are diversified and encode proteins with long and complex repeats . o o o o o o o o o o o o o o o o o o b - trivial o o o o o o o o o o o o o o o o o o o 23593923 developmental changes in sericin properties are controlled at the level of gene expression and splicing . o o o o o o o o o o o o o o o o 23593923 in galleria , mg-1 sericin is produced throughout larval life until the wandering stage , while the production of mg-2 and mg-3 reaches a peak during cocoon spinning . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23593960 is diacetyl a respiratory sensitizer ? a reconsideration using qsar , qmm , and competition experiments . o b - systematic o o o o o o o o o o o o o o o 23593960 concerns have been raised that diacetyl ( da ) might be a respiratory sensitizer based on its lumo energy similar to that of the respiratory allergen toluene-2,4-diisocyanate ( tdi ) and results of a local lymph node assay ( llna ) that reported an ec3 of 1.9 % . o o o o o b - systematic o o o o o o o o o o o o o o o o o o o o b - systematic o b - abbreviation o o o o o o o o o o o o o o o o o o o o 23593960 to better understand the concerns , we performed a systematic literature review and experimental competition reactions between da and tdi . o o o o o o o o o o o o o o o o o o o b - abbreviation o 23593960 the experimental evidence demonstrates that da is at least 400-fold less reactive than tdi . o o o o o o o o o o o o o b - abbreviation o 23593960 the literature review finds evidence that the ec3 for da is actually > 11 % . o o o o o o o o o o o o o o o o 23593960 we conclude that da is unlikely to have significant respiratory sensitization potential . o o o o o o o o o o o o o 23594296 investigation of aqueous stability of taxol in different release media . o o o o o b - trivial o o o o o 23594296 abstract in the present study , the aqueous stability of taxol in different aqueous media and immiscible aqueous / organic systems at 37 ° c was investigated . o o o o o o o o o o b - trivial o o o o o o o o o o o o o o o o o o 23594296 the aqueous media included phosphate buffered saline ( pbs ) and pbs containing 10 % methanol , 10 % ethanol , 10 % hydroxypropyl β-cyclodextrin ( hp-βcd ) , 1 % sodium citrate and 1 % o o o o b - systematic o o o o o o o o o o b - systematic o o o b - systematic o o o b - systematic i - systematic o b - abbreviation o o o o b - systematic i - systematic o o o 23594296 tween 80 . b - trivial i - trivial o 23594296 the immiscible systems consisted of pbs / octanol , pbs / dichloromethane , pbs / chloroform and pbs / ethyl acetate . o o o o o o o b - systematic o o o b - systematic o o o b - trivial o o o b - systematic i - systematic o 23594296 the concentrations of taxol and related derivatives in each of the media were determined through the high - performance liquid chromatography assay . o o o b - trivial o o o o o o o o o o o o o o o o o o o 23594296 results showed that hydrolysis and epimerization were two major types of degradation for taxol in the aqueous media starting from the initial hours of contact ( 6 hours ) . o o o o o o o o o o o o o b - trivial o o o o o o o o o o o o o o o o 23594296 addition of tween 80 to pbs moderately increased the aqueous stability of taxol . o o b - trivial i - trivial o o o o o o o o b - trivial o 23594296 as well , using pbs containing 10 % hp-βcd inhibited the taxol hydrolysis , while epimerization still in process . o o o o o o o o b - abbreviation o o b - trivial o o o o o o o o 23594296 in the case of immiscible systems , except for pbs / ethyl acetate system , no evidences of taxol hydrolysis were observed . o o o o o o o o o o o b - systematic i - systematic o o o o o b - trivial o o o o 23594296 meanwhile , epimerization of taxol in pbs / dichloromethane and pbs / chloroform systems underwent due to the ability of c - cl bonds to form hydrogen bonding with the hydroxyl group of c7 of taxol . o o o o b - trivial o o o b - systematic o o o b - trivial o o o o o o o b - formula o b - formula o o o b - systematic o o o b - systematic o o o o b - trivial o 23594299 automated actuation of nasal spray products : effect of hand - related variability on the in vitro performance of flonase nasal spray . o o o o o o o o o o o o o o o o o o o o o o o 23594299 abstract objective : to determine if patient - related variability for adults and children recorded during hand spraying of flonase with an instrumented nasal spray results in significant differences in spray weight , droplet size or spray pattern . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594299 methods : o o 23594299 settings derived from adult and pediatric participants hand - spraying nasal sprays were implemented into force and velocity - controlled automated actuators . o o o o o o o o o o o o o o o o o o o o o o o 23594299 spray weight , droplet size distribution and spray pattern tests were performed using iterations of actuation force ( af ) and force rise , hold and fall times . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594299 travel , actuation velocity and release velocity settings were also investigated . o o o o o o o o o o o o 23594299 results : o o 23594299 the variability measured in adult - derived actuator settings did not result in any differences in spray weight , but pediatric participants spraying with low af and/or compression velocity ( cv ) were predicted to receive a partial dose or no dose at all under some circumstances . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594299 droplet size characteristics were sensitive to the hand - based variability , with actuation force , force rise time and cv hand - related settings all resulting in significant differences in the droplet size . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594299 conclusions : o o 23594299 this study demonstrated how variability in hand spraying by adults and pediatric patients could result in differences in nasal spray characteristics , thus demonstrating the importance of monitoring how the prospective patient groups are likely to use a nasal spray . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594310 signatures of fano interferences in the electron energy loss spectroscopy and cathodoluminescence of symmetry - broken nanorod dimers . o o o o o o o o o o o o o o o o o o o 23594310 through numerical simulation , we predict the existence of the fano interference effect in the electron energy loss spectroscopy ( eels ) and cathodoluminescence ( cl ) of symmetry - broken nanorod dimers that are heterogeneous in material composition and asymmetric in length . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594310 the differing selection rules of the electron probe in comparison to the photon of a plane wave allow for the simultaneous excitation of both optically bright and dark plasmons of each monomer unit , suggesting that fano resonances will not arise in eels and cl . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594310 yet , interferences are manifested in the dimer 's scattered near- and far - fields and are evident in eels and cl due to the rapid π-phase offset in the polarizations between super - radiant and subradiant hybridized plasmon modes of the dimer as a function of the energy loss suffered by the impinging electron . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594310 depending upon the location of the electron beam , we demonstrate the conditions under which fano interferences will be present in both optical and electron spectroscopies ( eels and cl ) as well as a new class of fano interferences that are uniquely electron - driven and are absent in the optical response . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594310 among other things , the knowledge gained from this work bears impact upon the design of some of the world 's most sensitive sensors , which are currently based upon fano resonances . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594687 post - surgical thyroid ablation with low or high radioiodine activities results in similar outcomes in intermediate risk differentiated thyroid cancer patients . o o o o o o o o o o o o o o o o o o o o o o o 23594687 background : o o 23594687 in differentiated thyroid cancer ( dtc ) patients at intermediate risk of recurrences , no evidences are provided regarding the optimal radioactive iodine ( rai ) activity to be administered for post - surgical thyroid ablation . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594687 methods : o o 23594687 this study aimed to evaluate the impact of rai activities on the outcome of 225 dtc patients classified as intermediate risk , treated with low ( 1110 - 1850 mbq ) or high rai activities ( ≥3700 mbq ) . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594687 results : o o 23594687 six - eighteen months after ablation remission was observed in 60.0 % of patients treated with low and in 60 % of those treated with high rai activities , biochemical disease was found in 18.8 % of patients treated with low and in 14.3 % of patients treated with high rai activities , metastatic disease was found in 21.2 % of patients treated with low and in 25.7 % of patients treated with high rai activities ( p=0.56 ) . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594687 at the last follow - up ( low activities , median 4.2 years : high activities median 6.9 years ) remission was observed in 76.5 % of patients treated with low and in 72.1 % of patients treated with high rai activities , persistent disease was observed in 18.8 % of patients treated with low and in 23.5 % of patients treated with high rai activities , recurrent disease was 2.4 % in patients treated with low and 2.1 % in patients treated with high rai activities , deaths occurred in 2.4 % of patients treated with low and in 2.1 % of patients treated with high rai activities ( p=0.87 ) . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594687 conclusion : o o 23594687 our study provides the first evidence that in dtc patients at intermediate risk , high rai activities at ablation have no major advantage over low activities . o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594789 restoration of cardiac tissue thyroid hormone status in experimental hypothyroidism : a dose - response study in female rats . o o o o b - family i - family o o o o o o o o o o o o o o 23594789 thyroid hormones ( ths ) play a pivotal role in regulating cardiovascular homeostasis . b - family i - family o o o o o o o o o o o o 23594789 to provide a better understanding of the coordinated processes that govern cardiac th bioavailability , this study investigated the influence of serum and cardiac th status on the expression of th transporters and cytosolic binding proteins in the myocardium . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594789 in addition , we sought to determine if administration of t3 ( instead of t4 ) improves the relationship between ths in serum and cardiac tissue , and cardiac function over a short - term treatment period . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594789 adult female sd rats were made hypothyroid by seven weeks treatment with the anti - thyroid drug ptu ( 6-n - propyl-2-thiouracil ) . o o o o o o o o o o o o o o o o o b - abbreviation o b - systematic i - systematic i - systematic o o 23594789 after establishing hypothyroidism , rats were assigned to one of five graded t3 ( triiodothyronine ) dosages plus ptu for a two week dose - response experiment . o o o o o o o o o o o o o o b - trivial o o o b - abbreviation o o o o o o o o o 23594789 untreated , age matched rats served as euthyroid controls . o o o o o o o o o o 23594789 ptu was associated with depressed serum and cardiac tissue t3 and t4 levels , arteriolar atrophy , altered th transporter and cytosolic th binding protein expression , fetal gene re - expression , and cardiac dysfunction . b - abbreviation o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23594789 short - term administration of t3 led to a mismatch between serum and cardiac tissue th levels . o o o o o o o o o o o o o o o o o o 23594789 normalization of serum t3 levels was not associated with restoration of cardiac tissue t3 levels or cardiac function . o o o o o o o o o o o o o o o o o o o 23594789 in fact , a 3 fold higher t3 dosage was necessary to normalize cardiac tissue t3 levels and cardiac function . o o o o o o o o o o o o o o o o o o o o o 23594789 importantly , this study provides the first comprehensive data on the relationship between altered th status ( serum and cardiac tissue ) , cardiac function , and the coordinated in vivo changes in cardiac th membrane transporters and cytosolic th binding proteins in altered th states . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595055 brominated skeletal components of the marine demosponges , aplysina cavernicola and ianthella basta : analytical and biochemical investigations . o o o o o o o o o o o o o o o o o o o 23595055 demosponges possess a skeleton made of a composite material with various organic constituents and/or siliceous spicules . o o o o o o o o o o o o o o o o o 23595055 chitin is an integral part of the skeleton of different sponges of the order verongida . o o o o o o o o o o o o o o o o 23595055 moreover , sponges of the order verongida , such as aplysina cavernicola or ianthella basta , are well - known for the biosynthesis of brominated tyrosine derivates , characteristic bioactive natural products . o o o o o o o o o o o o o o o o o o o o o o o o b - trivial i - trivial o o o o o o o 23595055 it has been unknown so far whether these compounds are exclusively present in the cellular matrix or whether they may also be incorporated into the chitin - based skeletons . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595055 in the present study , we therefore examined the skeletons of a. cavernicola and i. basta with respect to the presence of bromotyrosine metabolites . o o o o o o o o o o o o o o o o o o o o o o b - systematic o o 23595055 the chitin - based - skeletons isolated from these sponges indeed contain significant amounts of brominated compounds , which are not easily extractable from the skeletons by common solvents , such as meoh , as shown by hplc analyses in combination with nmr and ir spectroscopic measurements . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o b - formula o o o o o o o o o o o o o o o 23595055 quantitative potentiometric analyses confirm that the skeleton - associated bromine mainly withstands the meoh - based extraction . o o o o o o o o o b - systematic o o o b - formula o o o o 23595055 this observation suggests that the respective , but yet unidentified , brominated compounds are strongly bound to the sponge skeletons , possibly by covalent bonding . o o o o o o o o o o o o o o o o o o o o o o o o o o 23595055 moreover , gene fragments of halogenases suggested to be responsible for the incorporation of bromine into organic molecules could be amplified from dna isolated from sponge samples enriched for sponge - associated bacteria . o o o o o o o o o o o o o o b - systematic o o o o o o o o o o o o o o o o o o o 23595057 marine nutraceuticals : prospects and perspectives . by se - kwon kim , crc press , 2013 ; 464 pages . price £ 108.00 , isbn 978 - 1 - 4665 - 1351 - 8 . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595057 the following paragraphs are reproduced from the publisher 's website [ 1 ] . o o o o o o o o o o o o o o 23595057 there is a great deal of consumer interest in natural bioactive substances due to their health benefits . o o o o o o o o o o o o o o o o o o 23595057 offering the potential to provide valuable nutraceuticals and functional food ingredients , marine - derived compounds are an abundant source of nutritionally and pharmacologically active agents , with both chemical diversity and complexity . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595057 functional ingredients derived from marine algae , invertebrates , vertebrates , and microorganisms can help fill the need for novel bioactives to treat chronic conditions such as cancer , microbial infections , and inflammatory processes . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595419 highly selective lithium recovery from brine using a λ-mno2-ag battery . o o b - systematic o o o o o o o o 23595419 the demand for lithium has greatly increased with the rapid development of rechargeable batteries . o o o b - systematic o o o o o o o o o o o 23595419 currently , the main lithium resource is brine lakes , but the conventional lithium recovery process is time consuming , inefficient , and environmentally harmful . o o o o b - systematic o o o o o o o o b - systematic o o o o o o o o o o o o 23595419 rechargeable batteries have been recently used for lithium recovery , and consist of lithium iron phosphate as a cathode . o o o o o o o b - systematic o o o o o b - systematic i - systematic i - systematic o o o o 23595419 these batteries feature promising selectivity between lithium and sodium , but they suffer from severe interference from coexisting magnesium ions , an essential component of brine , which has prompted further study . o o o o o o b - systematic o b - systematic o o o o o o o o o b - systematic o o o o o o o o o o o o o o 23595419 this study reports on a highly selective and energy - efficient lithium recovery system using a rechargeable battery that consists of a λ-mno2 positive electrode and a chloride - capturing negative electrode . o o o o o o o o o o o b - systematic o o o o o o o o o o o o o o o b - systematic o o o o o 23595419 this system can be used to recover lithium from brine even in the presence of magnesium ions as well as other dissolved cations . o o o o o o o b - systematic o o o o o o o b - systematic o o o o o o o o 23595419 in addition , lithium recovery from simulated brine is successfully demonstrated , consuming 1.0 w h per 1 mole of lithium recovered , using water similar to that from the artificial brine , which contains various cations ( mole ratio : o o o b - systematic o o o o o o o o o o o o o o o o b - systematic o o o o o o o o o o o o o o o o o o o o 23595419 na / li b - formula o b - formula 23595419 ≈ 15.7 , k / li ≈ 2.2 , mg / li ≈ 1.9 ) . o o o b - formula o b - formula o o o b - formula o b - formula o o o o 23595510 nuclear magnetic resonance study of ion adsorption on microporous carbide - derived carbon . o o o o o o o o o b - family o o b - systematic o 23595510 a detailed understanding of ion adsorption within porous carbon is key to the design and improvement of electric double - layer capacitors , more commonly known as supercapacitors . o o o o o o o o b - systematic o o o o o o o o o o o o o o o o o o o o 23595510 in this work nuclear magnetic resonance ( nmr ) spectroscopy is used to study ion adsorption in porous carbide - derived carbons . o o o o o o o o o o o o o o o o o o b - family o o b - family o 23595510 these predominantly microporous materials have a tuneable pore size which enables a systematic study of the effect of pore size on ion adsorption . o o o o o o o o o o o o o o o o o o o o o o o o 23595510 multinuclear nmr experiments performed on the electrolyte anions and cations reveal two main environments inside the carbon . o o o o o o o o o o o o o o o o b - systematic o 23595510 in - pore ions ( observed at low frequencies ) are adsorbed inside the pores , whilst ex - pore ions ( observed at higher frequencies ) are not adsorbed and are in large reservoirs of electrolyte between carbon particles . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o b - systematic o o 23595510 all our experiments were carried out in the absence of an applied electrical potential in order to assess the mechanisms related to ion adsorption without the contribution of electrosorption . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595510 our results indicate similar adsorption behaviour for anions and cations . o o o o o o o o o o o 23595510 furthermore , we probe the effect of sample orientation , which is shown to have a marked effect on the nmr spectra . o o o o o o o o o o o o o o o o o o o o o o o 23595510 finally , we show that a ( 13)c →(1)h cross polarisation experiment enables magnetisation transfer from the carbon architecture to the adsorbed species , allowing selective observation of the adsorbed ions and confirming our spectral assignments . o o o o o o b - formula i - formula o o o o o o o o o b - systematic o o o o o o o o o o o o o o o o o o o 23595554 monitoring agricultural rodenticide use and secondary exposure of raptors in scotland . o o o o o o o o o o o o 23595554 despite the documented risk of secondary poisoning to non - target species by anticoagulant rodenticides there is no statutory post - approval monitoring of their use in the uk . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595554 this paper presents results from two scottish monitoring schemes for the period 2000 - 2010 ; recording rodenticide use on arable farms and the presence of residues in raptor carcasses . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595554 more than three quarters of arable farms used anticoagulant rodenticides ; predominately the second generation compounds difenacoum and bromadiolone . o o o o o o o o o o o o o o o o b - trivial o b - trivial o 23595554 there was widespread exposure to anticoagulant rodenticides in liver tissues of the raptor species tested and the residues encountered generally reflected agricultural use patterns . o o o o o o o o o o o o o o o o o o o o o o o o o 23595554 as found in other studies , red kites ( milvus milvus ) appeared to be particularly vulnerable to rodenticide exposure , 70 % of those sampled ( n = 114 ) contained residues and 10 % died as a result of rodenticide ingestion . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595554 more unexpectedly , sparrowhawks ( accipiter nisus ) , which prey almost exclusively on birds , had similar exposure rates to species which prey on rodents . o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595554 although , with the exception of kites , confirmed mortality from rodenticides was low , the widespread exposure recorded is concerning . o o o o o o o o o o o o o o o o o o o o o o 23595554 particularly when coupled with a lack of data about the sub - lethal effects of these compounds . o o o o o o o o o o o o o o o o o o 23595554 this raises questions regarding whether statutory monitoring of use is needed ; both to address whether there are deficiencies in compliance with approval conditions or whether the recommended risk management procedures are themselves adequate to protect non - target wildlife . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595692 pine oil effects on chemical and thermal injury in mice and cultured mouse dorsal root ganglion neurons . b - trivial i - trivial o o o o o o o o o o o o o o o o 23595692 a commercial resin - based pine oil ( po ) derived from pinus palustris and pinus elliottii was the major focus of this investigation . o o o o o b - trivial i - trivial o o o o o o o o o o o o o o o o o o 23595692 extracts of pine resins , needles , and bark are folk medicines commonly used to treat skin ailments , including burns . o o o o o o o o o o o o o o o o o o o o o o 23595692 the american burn association estimates that 500,000 people with burn injuries receive medical treatment each year ; one - half of us burn victims are children , most with scald burns . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595692 this systematic study was initiated as follow - up to personal anecdotal evidence acquired over more than 10 years by mh bhattacharyya regarding po 's efficacy for treating burns . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595692 the results demonstrate that po counteracted dermal inflammation in both a mouse ear model of contact irritant - induced dermal inflammation and a second degree scald burn to the mouse paw . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23595692 furthermore , po significantly counteracted the tactile allodynia and soft tissue injury caused by the scald burn . o o o o o o o o o o o o o o o o o o 23595692 in mouse dorsal root ganglion neuronal cultures , po added to the medium blocked adenosine triphosphate - activated , but not capsaicin - activated , pain pathways , demonstrating specificity . o o o o o o o o o o o o o o b - systematic i - systematic o o o o o b - trivial o o o o o o o o o 23595692 these results together support the hypothesis that a pine - oil - based treatment can be developed to provide effective in - home care for second degree burns . o o o o o o o o b - trivial i - trivial i - trivial o o o o o o o o o o o o o o o o o o 23595692 copyright © o o 23595692 2013 john wiley & sons , ltd. o o o o o o o 23596084 influence of the molecular structure of surface - attached poly(n - alkyl acrylamide ) coatings on the interaction of surfaces with proteins , cells and blood platelets . o o o o o o o o o b - family i - family i - family i - family i - family o o o o o o o o o o o o o o 23596084 blood protein adsorption and blood platelet adhesion onto surface - attached poly(alkylacrylamide ) networks that exhibit small and systematic variations in chemical composition are investigated . o o o o o o o o o o o b - family i - family o o o o o o o o o o o o o 23596084 the polymer coatings are generated by depositing a thin layer of benzophenone - group - containing copolymer onto a solid substrate , followed by photo crosslinking and simultaneous surface - attachment . o o o o o o o o o o o b - systematic o o o o o o o o o o o o o o o o o o o o 23596084 the correlation of the swelling of the obtained surface - attached networks with the adsorption of blood proteins and cellular adhesion is studied . o o o o o o o o o o o o o o o o o o o o o o o o 23596084 the swollen surface - attached layers are inert to blood proteins and platelet cells . o o o o o o o o o o o o o o o 23596084 these results suggest that the hydrogel - coated materials are promising candidates for the generation of hemocompatible surfaces . o o o o o o o o o o o o o o o o o o o 23596091 the effect of the hydrophilic / hydrophobic ratio of polymeric micelles on their endocytosis pathways into cells . o o o o o o o o o o o o o o o o o o 23596091 fluorescein isothiocyanate ( fitc ) , a fluorescent probe , is coupled to amphiphilic monomethoxy poly(ethylene glycol)-block - poly(ε-caprolactone ) b - systematic i - systematic o b - abbreviation o o o o o o o o o o b - systematic i - systematic i - systematic i - systematic i - systematic i - systematic 23596091 ( mpeg - pcl ) copolymers . o b - abbreviation i - abbreviation i - abbreviation o o o 23596091 fitc - labeled mpeg - pcl copolymers self - assemble into micelles through the solvent evaporation method . b - abbreviation i - abbreviation i - abbreviation i - abbreviation i - abbreviation i - abbreviation o o o o o o o o o o o o 23596091 the cellular internalization is examined using fluorescence microscopy on incubation of nih-3t3 fibroblasts with micelles or free fitc solution . o o o o o o o o o o o o o o o o o b - abbreviation o o 23596091 the effect of the hydrophilic / hydrophobic ratio on the endocytosis mechanisms is evaluated by fluorescence microscopy on culturing of human hepatoblastoma cells and human umbilical vein endothelial cells , individually , mixed with the micelles holding the same parameters including micelle size , shape , and surface charges . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23596325 in vivo hepatic lipid quantification using mrs at 7 t in a mouse model of glycogen storage disease type 1a . o o o o o o o o o o o o o o o o o o o o o 23596325 the assessment of liver lipid content and composition is needed in preclinical research to investigate steatosis and steatosis - related disorders . o o o o o o o o o o o o o o o o o o o o o o 23596325 the purpose of this study was to quantify in vivo hepatic fatty acid content and composition using a method based on short echo - time proton magnetic resonance spectroscopy at 7t. mouse model of glycogen storage disease type 1a with inducible liver - specific deletion of the glucose-6-phosphatase gene ( l - g6pc-/- ) and control mice were fed a standard diet or a high fat / high sucrose diet ( hf / hs ) during 9 months . o o o o o o o o o o o b - family i - family o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o b - trivial o o o o o o o o o o 23596325 in control mice , hepatic lipid content was found significantly higher with hf / hs diet than with standard diet . o o o o o o o o o o o o o o o o o o o o o 23596325 as expected , hepatic lipid content was already elevated in l - g6pc-/- mice fed a standard diet compared to control mice . o o o o o o o o o o o o o o o o o o o o o o o 23596325 l - g6pc-/- mice rapidly developed steatosis which was not modified by hf / hs diet . o o o o o o o o o o o o o o o o o 23596325 on standard diet , estimated amplitudes from olefinic protons were found significantly higher in l - g6pc/- mice compared to that in control mice . o o o o o o o o o o o o o o o o o o o o o o o o o 23596325 l - g6pc-/- mice showed no noticeable polyunsaturation from diallylic protons . o o o o o o o o o o o o 23596325 total unsaturated fatty acid indexes measured by gas chromatography were in agreement with mrs measurements . o b - family i - family i - family o o o o o o o o o o o o 23596325 these results showed the great potential of high magnetic field mrs to follow the diet impact and lipid alterations in mouse liver . o o o o o o o o o o o o o o o o o o o o o o o 23596359 exploring the energy landscapes of cyclic tetrapeptides with discrete path sampling . o o o o o b - family i - family o o o o o 23596359 cyclic tetrapeptides are an important class of biologically active molecules that exhibit interesting conformational dynamics , with slow interconversion of several different structures . b - family i - family o o o o o o o o o o o o o o o o o o o o o o 23596359 we present calculations on their energy landscapes using discrete path sampling . o o o o o o o o o o o o 23596359 in acyclic peptides and large cyclic peptides , isomers containing cis - peptide groups are much less stable than the all - trans isomers and separated from them by large barriers . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23596359 strain in small cyclic peptides causes the cis and trans isomers to be closer in energy and separated by much lower barriers . o o o o o o o o o o o o o o o o o o o o o o o 23596359 if d - amino acids or proline residues are introduced , isomers containing cis - peptides become more stable than the all - trans structures . o b - family i - family i - family i - family o b - trivial o o o o o o o o o o o o o o o o o o o 23596359 we also show that changing the polarity of the solvent has a significant effect on the energy landscapes of cyclic tetrapeptides , causing changes in the orientations of the peptide groups and in the degree of intramolecular hydrogen bonding . o o o o o o o o o o o o o o o o o o o b - family i - family o o o o o o o o o o o o o o o o b - systematic o o 23596972 effect of moisture content , temperature and exposure time on the physical stability of chitosan powder and tablets . o o o o o o o o o o o o o o o o o o o 23596972 abstract context : o o o 23596972 chitosan does not rank highly regarding its employment as tablet filler due to certain limitations . o o o o o o o o o o o o o o o o 23596972 undesirable properties that limit its utilization as excipient in solid dosage forms include its hydration propensity that negatively affects tablet stability , strength and disintegration . o o o o o o o o o o o o o o o o o o o o o o o o o o 23596972 objective : the objective of this study was to investigate the physical stability of chitosan powder , mixtures , granules and tablets under accelerated conditions such as elevated temperatures and humidity over different periods of time . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23596972 methods : selected physico - chemical properties of pure chitosan powder , physical mixtures of chitosan with kollidon ® va64 ( basf , ludwigshafen , germany ) , chitosan granules , as well as tablets were evaluated under conditions of elevated humidity and temperature . o o o o o o o o o o o o o o o o o o o b - identifier o o o o o o o o o o o o o o o o o o o o o o o o o 23596972 results and discussion : o o o o 23596972 the physical stability of chitosan tablets exhibited sensitivity towards varying exposure conditions . o o o o o o o o o o o o o 23596972 it was furthermore evident that the presence of moisture ( sorbed water ) had a marked influence on the physical stability of chitosan powder and tablets . o o o o o o o o o o o o o o o o o o o o o o o o o o o 23596972 it was evident that the presence of kollidon ® va64 as well as the method of inclusion of this binder influenced the properties of chitosan tablets . o o o o o o o o o b - identifier o o o o o o o o o o o o o o o o o 23596972 the physical stability of chitosan powder deteriorated to a greater extent compared to that of the chitosan tablets , which were subjected to the same conditions . o o o o o o o o o o o o o o o o o o o o o o o o o o o 23596972 conclusion : it is recommended that tablets containing chitosan should be stored at a temperature not exceeding 25 ° c as well as at a relatively low humidity ( < 60 % ) to prevent deterioration of physical properties . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23596972 direct compression of chitosan granules which contained 5%w / w kollidon ® va64 produced the best formulation in terms of physical stability at the different conditions . o o o o o o o o o o o o b - identifier o o o o o o o o o o o o o o 23597047 2012 philip s. portoghese medicinal chemistry lectureship : structure - based approaches to ligands for g protein - coupled adenosine and p2y receptors , from small molecules to nanoconjugates . o o o o o o o o o o o o o o o o o o o b - trivial o o o o o o o o o o 23597047 adenosine receptor ( ars ) and p2y receptors ( p2yrs ) that respond to extracellular nucleosides / tides are associated with new directions for therapeutics . b - trivial o o o o o o o o o o o o o o b - multiple i - multiple i - multiple o o o o o o o o 23597047 the x - ray structures of the a2aar complexes with agonists and antagonists are examined in relationship to the g protein - coupled receptor ( gpcr ) superfamily and applied to drug discovery . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597047 much of the data on ar ligand structure from early sar studies , now is explainable from the a2aar x - ray crystallography . o o o o o o o o o o o o o o o o o o o o o o o o 23597047 the ligand - receptor interactions in related gpcr complexes can be identified by means of modeling approaches , e.g. molecular docking . o o o o o o o o o o o o o o o o o o o o o o 23597047 thus , molecular recognition in binding and activation processes has been studied effectively using homology modeling and applied to ligand design . o o o o o o o o o o o o o o o o o o o o o o 23597047 virtual screening has yielded new nonnucleoside ar antagonists , and existing ligands have been improved with knowledge of the receptor interactions . o o o o o o o o o o o o o o o o o o o o o o 23597047 new agonists are being explored for cns and peripheral therapeutics based on in vivo activity , such as chronic neuropathic pain . o o o o o o o o o o o o o o o o o o o o o o 23597047 ligands for receptors more distantly related to the x - ray template , i.e. p2yrs , have been introduced and are mainly used as pharmacological tools for elucidating the physiological role of extracellular nucleotides . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o b - family o 23597047 other ligand tools for drug discovery include fluorescent probes , radioactive probes , multivalent probes , and functionalized nanoparticles . o o o o o o o o o o o o o o o o o o o o 23597071 fabrication of quantum dot microarrays using electron beam lithography for applications in analyte sensing and cellular dynamics . o o o o o o o o o o o o o o o o o o 23597071 quantum dot ( qd ) o o o o o 23597071 based micro-/nanopatterned arrays are of broad interest in applications ranging from electronics , photonics , to sensor devices for biomedical purposes . o o o o o o o o o o o o o o o o o o o o o o 23597071 here , we report on a rapid , physico - chemically mild approach to generate high fidelity micropattern arrays of prefunctionalized water - soluble quantum dots using electron beam lithography . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597071 we show that such patterns retain their fluorescence and bioaffinity upon electron beam lithography and , based on the streptavidin - biotin interaction , allow for detection of proteins , colloidal gold nanoparticles and magnetic microparticles . o o o o o o o o o o o o o o o o o o o o o b - trivial o o o o o o o o o o o o o o o 23597071 furthermore , we demonstrate the applicability of qd based microarray patterns differing in their shape ( circles , squares , grid - like ) , size ( from 1 to 10 μm ) and pitch distance to study the adhesion , spreading and migration of human blood derived neutrophils . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597071 using live cell confocal fluorescence microscopy , we show that pattern geometry and pitch distance influence the adhesion , spreading and migratory behavior of neutrophils . o o o o o o o o o o o o o o o o o o o o o o o o o o 23597071 research reported in this work paves the way for producing qd microarrays with multiplexed functionalities relevant for applications in analyte sensing and cellular dynamics . o o o o o o o o o o o o o o o o o o o o o o o o o 23597099 2-methoxyjuglone induces apoptosis in hepg2 human hepatocellular carcinoma cells and exhibits in vivo antitumor activity in a h22 mouse hepatocellular carcinoma model . b - systematic o o o o o o o o o o o o o o o o o o o o o o 23597099 in order to discover anticancer agents from natural sources , an ethanol - soluble extract of the root bark of juglans cathayensis was investigated and showed cytotoxic effects against various human cancer cell lines . o o o o o o o o o o o b - systematic o o o o o o o o o o o o o o o o o o o o o o o 23597099 a subsequent phytochemical study on the etoac - soluble fraction determined 2-methoxyjuglone ( 1 ) as one of the main active constituents . o o o o o o b - formula o o o o b - systematic o o o o o o o o o o o 23597099 compound 1 was shown to be cytotoxic against hepg2 cells . o o o o o o o o o o o 23597099 morphological features of apoptosis were observed in 1-treated hepg2 cells , including cell shrinkage , membrane blebbing , nuclear condensation , and apoptotic body formation . o o o o o o o o o o o o o o o o o o o o o o o o o o 23597099 cell cycle analysis with propidium iodide staining showed that 1 induced cell cycle arrest at the s phase in hepg2 cells . o o o o b - trivial i - trivial o o o o o o o o o o o o o o o o 23597099 flow cytometric analysis with annexin v and propidium iodide staining demonstrated that 1 induced hepg2 cell apoptotic events in a dose - dependent manner ( 0 - 8 μg / ml ) . o o o o o o o b - trivial i - trivial o o o o o o o o o o o o o o o o o o o o o o o o 23597099 western blot analysis of apoptosis - related proteins revealed that 1 induces hepg2 cell apoptosis through mitochondrial cytochrome c - dependent activation of the caspase-9 and caspase-3 cascade pathway ( intrinsic pathway ) . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597099 an in vivo experiment using tumor - bearing mice showed that treatment with 1 at 0.5 and 1.0 mg / kg per day decreased the tumor mass by 56 % and 67 % , respectively . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597133 three - dimensional ab initio potential energy surface for h - co(x̃(2)a ' ) . o o o o o o o o o b - family i - family i - family i - family i - family o 23597133 we present an ab initio potential for the h - co(x̃(2)a ' ) complex in which the co bond length is varied and the long - range interactions between h and co are accurately represented . o o o o o o o o b - family i - family i - family i - family i - family o o o o b - formula o o o o o o o o o o o b - formula o b - formula o o o o 23597133 it was computed using the spin - unrestricted open - shell single and double excitation coupled cluster method with perturbative triples [ rhf - uccsd(t ) ] . o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597133 three doubly augmented correlation - consistent basis sets were utilized to extrapolate the correlation energy to the complete basis set limit . o o o o o o o o o o o o o o o o o o o o o o 23597133 more than 4400 data points were calculated and used for an analytic fit of the potential : long - range terms with inverse power dependence on the h - co distance r were fit to the data points for large r , the reproducing kernel hilbert space ( rkhs ) method was applied to the data at smaller distances . o o o o o o o o o o o o o o o o o o o o o o o o o o o b - formula o b - formula o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597133 our potential was compared with previous calculations and with some data extracted from spectroscopy . o o o o o o o o o o o o o o o 23597133 furthermore , it was used in three - dimensional discrete variable representation ( dvr ) calculations of the vibrational frequencies and rotational constants of hco , which agree very well with the most recently measured data . o o o o o o o o o o o o o o o o o o o o o o o o b - formula o o o o o o o o o o o o 23597133 also the dissociation energy d0 = 0.623 ev of hco into h + co o o o o o o o o o b - formula o b - formula o b - formula 23597133 obtained from these calculations agrees well with experimental values . o o o o o o o o o o 23597133 finally , we made preliminary two - dimensional ( 2d ) calculations of the cross sections for rotationally inelastic h - co collisions with the co bond length fixed and obtained good agreement with recently published 2d results . o o o o o o o o o o o o o o o o o o o b - formula o b - formula o o o b - formula o o o o o o o o o o o o o 23597450 anti - inflammatory effect of prunetin via the suppression of nf-κb pathway . o o o o o b - trivial o o o o o o o 23597450 prunetin is an o - methylated isoflavone , which is found in prunus yedoensis . b - trivial o o b - family i - family i - family i - family o o o o o o o o 23597450 to date no report has been published on anti - inflammatory activities of prunetin . o o o o o o o o o o o o o b - trivial o 23597450 in the present study , the anti - inflammatory effect of prunetin on lps - stimulated raw 264.7 macrophage and lps - induced septic shock model were investigated . o o o o o o o o o o o b - trivial o o o o o o o o o o o o o o o o o 23597450 inducible nitric oxide synthase ( inos ) , cyclooxygenase-2 ( cox-2 ) , tumor necrosis factor-α ( tnf-α ) , interleukin-6 ( il-6 ) , and interleukin-1β ( il-1β ) expressions were determined by western blot and or realtime - pcr ( rt - pcr ) . o b - systematic i - systematic o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597450 to elucidate its underlying mechanism , nuclear factor - kappa b ( nf-κb ) activation and its downstream pathways were investigated by nf-κb transcription factor assay , reporter gene expression , and western blot . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597450 in vivo anti - inflammatory effects of prunetin were evaluated in lps - induced endotoxemia . o o o o o o o b - trivial o o o o o o o o 23597450 promoter assay revealed that prunetin inhibits lps - induced nitric oxide and prostaglandin e2 production through the suppression of inos and cox-2 at the transcriptional level . o o o o b - trivial o o o o b - systematic i - systematic o b - trivial i - trivial o o o o o o o o o o o o o 23597450 in addition , prunetin inhibits nf-κb - dependent inflammatory responses by modulating iκb kinase ( ikk)-inhibitor κbα ( iκbα)-nf-κb signaling . o o o b - trivial o o o o o o o o o o o o o o o o o 23597450 consistent with these results , prunetin significantly reduced serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide . o o o o o b - trivial o o o o o o o o o o o o o o o 23597450 these findings offer a potential mechanism for the anti - inflammatory activity of prunetin . o o o o o o o o o o o o o b - trivial o 23597490 anti - diabetic activity of embelin : involvement of cellular inflammatory mediators , oxidative stress and other biomarkers . o o o o o b - trivial o o o o o o o o o o o o o 23597490 embelin ( benzoquinone ) , an active constituent of methanolic extracts of the fruit of embelia basal ( myrsinaceae ) , was studied in high fat diet ( hfd)+streptozotocin ( stz ) diabetic rats . b - trivial o b - systematic o o o o o o o o o o o o o o o o o o o o o o o o o o o b - abbreviation o o o o 23597490 treatment of embelin ( 25 and 50mg / kg / day , p.o . ) for 3 weeks to hfd+stz diabetic rats elicited insignificant increase in body weight , reduced the elevated plasma glucose , glycosylated haemoglobin and pro - inflammatory mediators ( interleukin 6 and tumour necrosis factor α ) significantly . o o b - trivial o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o b - trivial o o o o o o o o o o o o o o o o o o o 23597490 furthermore , embelin treatment at both the doses significantly decreased the elevated malondialdehyde , restored depleted glutathione , antioxidant enzymes , superoxide dismutase and catalase in liver . o o o o o o o o o o o o b - trivial o o o b - trivial o o o o b - trivial o o o o o o 23597490 the increased lipid profiles in hfd+stz diabetic rats were also reduced by embelin treatment significantly . o o o o o o o o o o o o b - trivial o o o 23597490 embelin treatment to hfd+stz diabetic rats also improved the altered histoarchitecture of β-islets of pancreas and hepatocytes . b - trivial o o o o o o o o o o o o o o o o o 23597490 the embelin effect on progression of type 2 diabetes mellitus in rats appears to be through the inhibition of intracellular pro - inflammatory mediators , lowering of lipid profile and amelioration of oxidative stress . o b - trivial o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597490 considering the pharmacological activity profile of embelin , it is suggested that embelin be a useful diabetic modulator or adjuvant along with clinically effective anti - diabetic drugs in the treatment of type 2 diabetes mellitus and needs to be clinically evaluated on human subjects . o o o o o o b - trivial o o o o o b - trivial o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597507 phα1β toxin prevents capsaicin - induced nociceptive behavior and mechanical hypersensitivity without acting on trpv1 channels . o o o b - trivial o o o o o o o o o o o o o 23597507 phα1β toxin is a peptide purified from the venom of the armed spider phoneutria nigriventer , with markedly antinociceptive action in models of acute and persistent pain in rats . o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597507 similarly to ziconotide , its analgesic action is related to inhibition of high voltage activated calcium channels with more selectivity for n - type . o o o o o o o o o o o o o o o b - systematic o o o o o o o o o 23597507 in this study we evaluated the effect of phα1β when injected peripherally or intrathecally in a rat model of spontaneous pain induced by capsaicin . o o o o o o o o o o o o o o o o o o o o o o o b - trivial o 23597507 we also investigated the effect of phα1β on ca(2 + ) transients in cultured dorsal root ganglia ( drg ) neurons and hek293 cells expressing the trpv1 receptor . o o o o o o o o b - formula i - formula i - formula o o o o o o o o o o o o o o o o o o 23597507 intraplantar or intrathecal administered phα1β reduced both nocifensive behavior and mechanical hypersensitivity induced by capsaicin similarly to that observed with sb366791 , a specific trpv1 antagonist . o o o o o o o o o o o o o o b - trivial o o o o o b - identifier o o o o o o 23597507 peripheral nifedipine and mibefradil did also decrease nociceptive behavior induced by intraplantar capsaicin . o b - trivial o b - trivial o o o o o o o o b - trivial o 23597507 in contrast , ω-conotoxin mviia ( a selective n - type ca(2 + ) channel blocker ) was effective only when administered intrathecally . o o o o o o o o o o o b - formula i - formula i - formula o o o o o o o o o o 23597507 phα1β , mviia and sb366791 inhibited , with similar potency , the capsaicin - induced ca(2 + ) transients in drg neurons . o o o o b - identifier o o o o o o o b - trivial o o b - formula i - formula i - formula o o o o o 23597507 the simultaneous administration of phα1β and sb366791 inhibited the capsaicin - induced ca(2 + ) transients that were additive suggesting that they act through different targets . o o o o o o b - identifier o o b - trivial o o b - formula i - formula i - formula o o o o o o o o o o o o 23597507 moreover , phα1β did not inhibit capsaicin - activated currents in patch - clamp recordings of hek293 cells that expressed trpv1 receptors . o o o o o o b - trivial o o o o o o o o o o o o o o o o 23597507 our results show that phα1β may be effective as a therapeutic strategy for pain and this effect is not related to the inhibition of trpv1 receptors . o o o o o o o o o o o o o o o o o o o o o o o o o o o 23597510 nicotine primes the effect of cocaine on the induction of ltp in the amygdala . b - trivial o o o o b - trivial o o o o o o o o o 23597510 in human populations , there is a well - defined sequence of involvement in drugs of abuse , in which the use of nicotine or alcohol precedes the use of marijuana , which in turn , precedes the use of cocaine . o o o o o o o o o o o o o o o o o o o o o o o b - trivial o b - family o o o o o o o o o o o o o o b - trivial o 23597510 the term gateway hypothesis " describes this developmental sequence of drug involvement .’ This actually considers many lines as an example. For tsv files, how tortext defines the example that makes up the dataset?

pytorch / text

field #468