beginning 1 March 2024, Qiskit Runtime will require that circuits and observables are transformed to use only instructions supported by the system (referred to as instruction set architecture (ISA) circuits and observables) before being submitted to the primitives
This affects the existing V1 estimator, as supported here, as well as the newly introduced V2 one which is yet to be supported, see #1306
Nature also makes use of Qiskit Algorithms for which there is an open issue too on the same subject qiskit-community/qiskit-algorithms#164
https://docs.quantum.ibm.com/announcements/product-updates/2024-02-14-qiskit-runtime-primitives-update
This affects the existing V1 estimator, as supported here, as well as the newly introduced V2 one which is yet to be supported, see #1306
Nature also makes use of Qiskit Algorithms for which there is an open issue too on the same subject qiskit-community/qiskit-algorithms#164