Question: Can Pando be used on an unpaired multiomic dataset?

quadbio / Pando

Multiome GRN inference.

https://quadbio.github.io/Pando/

MIT License

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Question: Can Pando be used on an unpaired multiomic dataset? #35

Closed mitchTwoTimes closed 1 year ago

mitchTwoTimes commented 1 year ago

Is it possible to make a GRN using Pando on an integrated object like the one described here?

Thank you

joschif commented 1 year ago

Pando can be used on any object that has both RNA and ATAC modalities for each sample/cell. If one integrates two datasets and summarizes them into metacells or high-resolution clusters, this should work. We have done something similar here: https://www.nature.com/articles/s41586-022-05279-8