quinlan-lab / STRling

Detect novel (and reference) STR expansions from short-read data
MIT License
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Ignore inconsistent soft-clips #90

Closed hdashnow closed 3 years ago

hdashnow commented 3 years ago

When determining the bounds for a locus, ignore soft-clips that are inconsistent with the center mass. Ignore left soft-clips that are too far to the right, and right soft-clips that are too far to the left of the center mass. "Too far" is half the median fragment size.

Possible addition: re-calculate the center mass and far left and right bounds after removing those soft clips?