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raerose01 / deconstructSigs

deconstructSigs
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Mutational Signatures for mouse mutation data? #45

Open SNRNS opened 5 years ago

SNRNS commented 5 years ago

Hi,

I have MAF files from mice tumours, and I tried to extract mutational signatures from that.

The trinucleotideMatrix function does not recognise the BSgenome.Mmusculus.UCSC.mm10 genome.

Is it possible to compare the mutational spectrum of mouse tumours to the mutational signatures derived from human tumours? After all, mouse tumour models are supposed to resemble to a certain extent human tumours. (?)

Any idea about this?

Thanks, Alejandro