The only way to fight Grapple Guardian is to enter from the top door. Entering from the side doors spawns a fake Grapple Guardian actor and thus requires a room reload from the top. This causes issues for Door Lock and Room Rando where access to the top door can be blocked for various reasons, unless exclusions are in place. Changing the room so the fight trigger is accessible from any door removes all issues with reloading and makes it fully compatible for the two modes without needing to exclude the door.
The only way to fight Grapple Guardian is to enter from the top door. Entering from the side doors spawns a fake Grapple Guardian actor and thus requires a room reload from the top. This causes issues for Door Lock and Room Rando where access to the top door can be blocked for various reasons, unless exclusions are in place. Changing the room so the fight trigger is accessible from any door removes all issues with reloading and makes it fully compatible for the two modes without needing to exclude the door.