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rcedgar / muscle

Multiple sequence and structure alignment with top benchmark scores scalable to thousands of sequences. Generates replicate alignments, enabling assessment of downstream analyses such as trees and predicted structures.
https://drive5.com/muscle
GNU General Public License v3.0
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Segmentation fault (core dumped)riors #69

Closed MHassanSaeed closed 5 days ago

MHassanSaeed commented 8 months ago

Command used: muscle -align 1.fasta -output alignment.fasta

Error information: muscle 5.1.linux64 [] 528Gb RAM, 56 cores Built Feb 24 2022 03:16:15 (C) Copyright 2004-2021 Robert C. Edgar. https://drive5.com

WARNING: 7 duplicate labels

Input: 241 seqs, avg length 324490, max 2766791

00:00 133Mb CPU has 56 cores, running 24 threads Segmentation fault (core dumped)riors

rcedgar commented 8 months ago

please see issue #31

rcedgar commented 8 months ago

also, I think it is unlikely sequences of length ~300k are globally alignable, I can't think of an example of biological sequences this long which don't have re-arrangement events