UMAP for rare cell type detection

[JohnTigue]

• Tune up UMAP for outlier detection
• Then use gaussian density graph: inver is rareness (a la FIRE)

https://github.com/seandavi/awesome-single-cell:

FiRE - [python, R, C++] - Finder of rare entities (FiRE) helps identify rare cell types in voluminous single-cell datasets. Design of FiRE is inspired by the observation that rareness estimation of a particular data point is the flip side of measuring the density around it. In principle, FiRE uses the Sketching technique, a variant of locality sensitive hashing, to assign rareness score to every cell. Paper