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reimandlab / ActiveDriverDB

ActiveDriverDB
GNU Lesser General Public License v2.1
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Keep an eye on MANE project (primary isoforms) #149

Open krassowski opened 5 years ago

krassowski commented 5 years ago

I've just read about The Matched Annotation from the NCBI and EBI project. It is a joint effort from NCBI and EBI to define a systematic mapping of primary transcripts between RefSeq (NM) and Ensembl (ENST), citing:

Our effort to select one high-quality transcript at all protein-coding loci, and to have this be consistent across all genomics resources, will give a consistent starting view of biology for researchers, whether the intent is to use it for reporting variants, comparative genomics or any other endeavour. That said, all the transcripts we annotate should always be considered and we are certainly NOT saying that biology can be simplified to a single transcript at each genomic locus.

This could be used in the future versions of ActiveDriverDB to select primary isoforms (just a suggestion). They plan to release a beta by the end of the year.

krassowski commented 5 years ago

There was an update in March this year: 53% of transcripts are now mapped and are accessible as part of Ensembl release 96, though it seems to be too early stage of the project to incorporate for this (2019) release of ADDB (plus it would take about a week or two to rework the current mapping).