search

reimandlab / ActivePathways

Integrative pathway enrichment analysis of multivariate omics data
101 stars 23 forks source link

miRNA results #24

Closed owehann closed 3 months ago

owehann commented 3 months ago

Hi, I want to know if the differential miRNA results are applicable to DPM.

reimand0 commented 3 months ago

Hi Owehann,

Thanks for your message. Directional integration should work for miRNAs too and it sounds like an interesting project. You should be able to prioritise individual miRNAs based on significance and fold-change directions, depending on how your datasets are set up.

However, pathway analysis is limited to gene functional annotations that are mostly available for protein-coding genes. Linking miR activity to protein-coding genes would be beneficial, or perhaps looking for miR target gene information as GMT files.

I hope this helps. Happy to discuss further offline.

Jüri

On Sun, Jul 14, 2024 at 11:40 owehann @.***> wrote:

Hi, I want to know if the differential miRNA results are applicable to DPM.

— Reply to this email directly, view it on GitHub https://github.com/reimandlab/ActivePathways/issues/24, or unsubscribe https://github.com/notifications/unsubscribe-auth/AETAF7IHTGVRNIZYBO2B3WLZMI2QLAVCNFSM6AAAAABK273EMCVHI2DSMVQWIX3LMV43ASLTON2WKOZSGQYDOMZTGAYDSOA . You are receiving this because you are subscribed to this thread.Message ID: @.***>