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resplab / epicR

R package for the Evaluation Platform in COPD (EPIC), an agent-based whole-disease model for projection of health and economic outcomes and COPD interventions.
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Treatment for smoking cessation #109

Open KateJohnson opened 4 years ago

KateJohnson commented 4 years ago

Treatment for smoking cessation (3 months of Nicotine Replacement Therapy) is given to all current smokers newly diagnosed with COPD, including false positive diagnoses. An increase in the OR for successfully quitting of 1.38 is being correctly applied to GOLD 0 and GOLD >0. However, it results in ~20% of COPD patients quitting and ~70% of GOLD 0's quitting. (See figures)

I think this is because smoking change is an event, and there are fewer competing events that can occur in GOLD 0, therefore it happens more often.

I'm leaving this bug because it doesn't bias my evaluation of case detection (it affects both arms equally). The overall smoking calibration (prevalence of current, former, and never smokers) is also still good.

Smoking Quitters.pdf SmokingPrevalence.pdf

KateJohnson commented 2 years ago

We're revisiting this issue in light of low exacerbation rates among diagnosed patients, thinking that the smoking cessation intervention (3 months of NRT) should be turned off when we're not evaluating case detection. Currently it's always on.

aminadibi commented 2 years ago

Turned off in https://github.com/resplab/epicR/commit/ab020308595c081d64cd1461241811381b926b41