Can we use SCA for oligomeric protein ?

reynoldsk / pySCA

A python implementation of the Statistical Coupling Analysis (SCA)

BSD 3-Clause "New" or "Revised" License

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Open raghav1986 opened 5 years ago

raghav1986 commented 5 years ago

Main idea of SCA is to use MSA as a foundation stone. My question does it equally reliable for oligomeric protein?

chemgeeklian commented 5 years ago

I don't think so if you can't get MSA of oligomeric proteins. BTW SCA is quite sensitive to quality of the data.