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The Bianchi Bilderbeek Bogaart Question answered
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Correlation between haplotype and mortality rate #31

Closed richelbilderbeek closed 3 years ago

richelbilderbeek commented 4 years ago

30 July 2020 15:07 5 KB From: [Frans] To: [Richel] Cc: [Geert]

Zoals net met je besproken richel ziet er echt super uit. We moeten even kijken in de literatuur of er al correlaties liggen tussen deceased patients and haplotypes.

richelbilderbeek commented 4 years ago

Nice: https://www.nature.com/articles/s10038-020-0808-9

Among them, the countries where the proportion of individuals with HLA-A11:01, HLA-A02:06, and HLA-B54:01 alleles are relatively high showed lower fatality rates as well as number of confirmed cases (Fig. 5). However, the significant correlations with fatality rates became not significant after adjusted by the frequency of S protein 614G-type virus in multiple regression analysis. These results suggest that individuals with HLA-A11:01, HLA-A02:06, or HLA-B54:01 might be protected from infection of SARS-CoV-2, although further studies are needed to investigate the effects of other potential confounding factors, such as different phases of outbreak, age of infected population, management of the pandemic. In SARS-CoV and MERS-CoV, several HLA genotypes have been reported to associate with susceptibility or resistance, including HLA-B07:03, HLA-B46:01, HLA-C08:01, HLA-C15:02, HLA-DRB103:01, HLA-DRB111:01, and HLA-DRB1*12:02 [23,24,25,26]

richelbilderbeek commented 4 years ago

May work, will ask @fransbianchi first.

richelbilderbeek commented 4 years ago

Well, there is no link between %binders that is TMH and frequency:

haplotype_perc_vs_f_tmh_binders phenotype_freq_vs_f_tmh_binders

richelbilderbeek commented 3 years ago

There is no, closing this Issue