The height of the tree in units of substitutions will be a factor:
when the tree is small (<< 0.1 substitutions) sequences will have many
constant sites, and the tree cannot be reliably recovered.
When the tree is large (>>1 substitutions), there will be saturations and
it will be impossible to recover the tree. In the example,
a distance of 1 is used (tree height = 10, mutation rate = 0.1),
but not explained why that is a good combination.
Some discussion around this would be useful.
Definitely! We have added this, also as a worked example in the Appendix,
section 'The effect of mutation rate'
Copy-paste from response letter:
Definitely! We have added this, also as a worked example in the Appendix, section 'The effect of mutation rate'