rmarkello / abagen

A toolbox for working with Allen Human Brain Atlas microarray expression data
https://abagen.readthedocs.io
BSD 3-Clause "New" or "Revised" License
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Question about atlas #224

Open joeyb87 opened 1 year ago

joeyb87 commented 1 year ago

Hello,

I am new to abagen and I still have couple questions after going through the user-guide. What we would like to do is to access the gene expression in the white matter structure. Since the provided DK atlas does not include the white matter structure, we are wondering whether we can directly access the gene expression based on the structure ID from 'Ontology' file.

Here are our questions:

  1. Our preliminary interest is to find the gene expression for white matter structures, such as corpus callosum, corona radiata, etc. However, the given DK atlas does not include these regions. We tried to input our own atlas, but the results are conflicting. Is there anyway we can directly access the gene expression, based on the structure ID being used in the toolkit? (For instance, is there a way to aggregate the gene expression for ‘corpus callosum’ using its ID (9222)?)

  2. If there is no simple way to access using the structure ID and we must provide the atlas, which MNI template does the toolkit use? The provided DK atlas doesn’t seem to match well with our MNI-152 linear template. Could you kindly let us know which MNI template was used to generate DK atlas in the toolkit?

Thank you in advance for all your help,