rmattson1008 / ornet

Organellar segmentation, tracking, and network modeling.
MIT License
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Literature review writing #20

Open rmattson1008 opened 1 year ago

rmattson1008 commented 1 year ago

Just a checklist of lit. review topics to check off. The easiest thing to work on when motivation is low

And more:

rmattson1008 commented 1 year ago

probably leave mitoloc out

rmattson1008 commented 1 year ago

I think I need to address methods that prioritize segmentation more (They don't see mito. as one holistic network, apply deep segmentation, analyze pieces of mito.) Example: Fischer, C. A. et al. MitoSegNet: easy-to-use deep learning segmentation for analyzing mitochondrial morphology. iScience 23, 101601. 2020

rmattson1008 commented 1 year ago

Shapes w bio names. perilamellar mitochondria. Is there a communication gap between the bio people and the classic ml people? Is mitochondrion a useful concept or is it just fun to write. Am I leaning too hard into the network perspective? example

magsol commented 1 year ago

Is there a communication gap between the bio people and the classic ml people?

Yes.

Is mitochondrion a useful concept or is it just fun to write?

Can't it be both? :)

Am I leaning too hard into the network perspective?

Depends. I think even more than the network perspective, we leaned too hard into the Gaussian-ness of mitochondria; they're decidedly not Gaussian. That said, I do think it's always worthwhile, when we're stuck, to simplify the problem--maybe take a page from that paper and look at three distinct morphologies, instead of arbitrary graphs--and go with that until we get some results that match our intuition. Then add in more complexity.