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rmnldwg / lymph

Python package for statistical modelling of lymphatic metastatic spread in head & neck cancer.
https://lymph-model.readthedocs.io
MIT License
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multiple modalities #26

Closed rmnldwg closed 1 year ago

rmnldwg commented 2 years ago

While the formalism with the observation matrix B and the data matrix C is quite elegant and general, it comes with significant performance issues as soon as one wants to use more than two diagnostic modalities. This is mainly because they grow really quickly with the number of modalities.

There might be a simple solution though: Instead of computing the probability for every possible combination of diagnoses given any possible hidden state, only compute the likelihood of the actually observed diagnoses given all possible hidden states. This would be a process carried out once, when the data is loaded and result in a matrix of size 2^N x P where N is the number of LNLs and P the number of patients.

rmnldwg commented 1 year ago

fixed by 5b8d69b49baa18c7297d03b791227307c5e57d1e