Ein zentraler Bestandteil einer erfolgreichen Erregersurveillance ist das Verständnis der Verbreitung eines Erregers sowie seiner pathogenen Eigenschaften. Hierbei stellt das Wissen über das Erregergenom eine wichtige Informationsquelle dar. So erlaubt der Nachweis von Mutationen im Genom eines Erregers, Verwandtschaftsbeziehungen zu rekonstruie...
I've noticed that around 30% of German sequences submitted to GISAID from Germany via RKI suddenly have spurious mutations:
G7160T
G1296T
And often also a few of the following:
T27138A
T27132A
A18585G
T6928A
Given that the pair of G7160T and G1296T appeared all of a sudden, only in Germany and across a large number of lineages/clades, it is almost certain that these are fake mutations.
Could you look into what gave rise to these? Maybe someone changed primers and the primers are incorrectly trimmed?
I've noticed that around 30% of German sequences submitted to GISAID from Germany via RKI suddenly have spurious mutations:
And often also a few of the following:
Given that the pair of G7160T and G1296T appeared all of a sudden, only in Germany and across a large number of lineages/clades, it is almost certain that these are fake mutations.
Could you look into what gave rise to these? Maybe someone changed primers and the primers are incorrectly trimmed?
Here is a list of suspicious sequences: