Dear fellows,
I have a question about the interpretation of MRPRESSO results.
like this,
$Main MR results
Exposure MR Analysis Causal Estimate Sd T-stat P-value
1 E1_effect Raw 0.5390120 0.01948158 27.66778 1.446937e-31
2 E1_effect Outlier-corrected 0.5092231 0.01256607 40.52366 4.621318e-37
$MR-PRESSO results
$MR-PRESSO results$Global Test
$MR-PRESSO results$Global Test$RSSobs
[1] 133.0666
"$MR-PRESSO results$Global Test$Pvalue
[1] "<0.001"" means that horizontal pleitropy exists for my study and then MR-PRESSO outlier test was performed. But I don't understand the meaning of "$MR-PRESSO results$Distortion Test$Outliers Indices
[1] 46 48 49 50" . What is 46,48,49,50? I have only 42 SNPs in this study and how can I know which SNP/SNPs causes/cause the pleitropy.
Dear fellows, I have a question about the interpretation of MRPRESSO results. like this, $
Main MR resultsExposure MR Analysis Causal Estimate Sd T-stat P-value 1 E1_effect Raw 0.5390120 0.01948158 27.66778 1.446937e-31 2 E1_effect Outlier-corrected 0.5092231 0.01256607 40.52366 4.621318e-37$
MR-PRESSO results$MR-PRESSO results$Global Test$MR-PRESSO results$Global Test$RSSobs [1] 133.0666$
MR-PRESSO results$Global Test$Pvalue [1] "<0.001"$
MR-PRESSO results$Outlier TestRSSobs Pvalue 1 1.499262e-01 1 2 5.872002e-02 1 3 4.250417e-03 1 4 7.533861e-02 1 5 3.543814e-04 1 6 1.502287e-02 1 7 1.872460e-02 1 8 5.469580e-03 1 9 5.301179e-03 1 10 1.343906e-02 1 11 1.006311e-01 1 12 6.050137e-03 1 13 1.170312e-02 1 14 2.530864e-02 1 15 1.796098e-03 1 16 2.272649e-03 1 17 9.476584e-02 1 18 3.864017e-03 1 19 2.870581e-02 1 20 7.913335e-02 1 21 1.261307e-05 1 22 1.958344e-02 1 23 1.383276e-02 1 24 2.425189e-02 1 25 4.001595e-02 1 26 2.351414e-03 1 27 9.259216e-02 1 28 1.355804e-02 1 29 8.254941e-03 1 30 3.172250e-02 1 31 1.602495e-02 1 32 3.503315e-02 1 33 9.739462e-04 1 34 4.232503e-03 1 35 4.209395e-02 1 36 4.209340e-05 1 37 9.529412e-03 1 38 3.809698e-02 1 39 5.848238e-04 1 40 1.321789e-01 1 41 5.382543e-04 1 42 8.689052e-05 1 43 9.247444e-04 1 44 3.451819e-03 1 45 8.677591e-03 1 46 5.567235e-01 <0.05 47 3.259649e-01 0.2 48 5.211657e-01 <0.05 49 8.893741e-01 <0.05 50 5.048754e-01 <0.05$
MR-PRESSO results$Distortion Test$MR-PRESSO results$Distortion Test$Outliers Indices[1] 46 48 49 50$
MR-PRESSO results$Distortion Test$Distortion CoefficientE1_effect 5.849878$
MR-PRESSO results$Distortion Test$Pvalue [1] 0.009"$
MR-PRESSO results$Global Test$Pvalue [1] "<0.001"" means that horizontal pleitropy exists for my study and then MR-PRESSO outlier test was performed. But I don't understand the meaning of "$MR-PRESSO results$Distortion Test$Outliers Indices[1] 46 48 49 50" . What is 46,48,49,50? I have only 42 SNPs in this study and how can I know which SNP/SNPs causes/cause the pleitropy.