Closed danielinteractive closed 1 month ago
+Simulation in a count data design Sequential analysis with a maximum of 3 looks (group sequential design), one-sided overall significance level 2.5%. +The results were simulated for a two-sample Wald-test (normal approximation), +H0: lambda(1) / lambda(2) = 1 *Theta H0*, power directed towards larger values, +H1: effect as specified, overdispersion = 1, planned cumulative sample size = c(40, 80, 120), +planned calendar times = c(X, X, X), +accrual time, +fixed *OR* variable follow-up time, *Order see sim survival* simulation runs = 1000, seed = -298806844. Stage 1 2 3 Planned information rate 33.3% 66.7% 100% Efficacy boundary (z-value scale) 3.471 2.454 2.004 Stage levels (one-sided) 0.0003 0.0071 0.0225 Cumulative power, alt. = 0 0 0.0070 0.0260 *effect size ratio OR lambda* Cumulative power, alt. = 0.2 0.0020 0.0650 0.2220 Cumulative power, alt. = 0.4 0.0060 0.2170 0.5470 Cumulative power, alt. = 0.6 0.0630 0.5810 0.8870 Cumulative power, alt. = 0.8 0.1780 0.8490 0.9880 Cumulative power, alt. = 1 0.3850 0.9840 1.0000 Stagewise number of subjects, alt. = 0 40.0 40.0 40.0 Stagewise number of subjects, alt. = 0.2 40.0 40.0 40.0 Stagewise number of subjects, alt. = 0.4 40.0 40.0 40.0 Stagewise number of subjects, alt. = 0.6 40.0 40.0 40.0 Stagewise number of subjects, alt. = 0.8 40.0 40.0 40.0 Stagewise number of subjects, alt. = 1 40.0 40.0 40.0 Expected number of subjects under H1, alt. = 0 119.7 Expected number of subjects under H1, alt. = 0.2 117.3 Expected number of subjects under H1, alt. = 0.4 111.1 Expected number of subjects under H1, alt. = 0.6 94.2 Expected number of subjects under H1, alt. = 0.8 78.9 Expected number of subjects under H1, alt. = 1 65.2 Conditional power (achieved), alt. = 0 0.0614 0.0590 *does not yet exist* Conditional power (achieved), alt. = 0.2 0.1665 0.2179 Conditional power (achieved), alt. = 0.4 0.3083 0.3925 Conditional power (achieved), alt. = 0.6 0.5192 0.6181 Conditional power (achieved), alt. = 0.8 0.6872 0.7320 Conditional power (achieved), alt. = 1 0.8433 0.8490 Exit probability for efficacy, alt. = 0 0 0.0070 0.0190 Exit probability for efficacy, alt. = 0.2 0.0020 0.0630 0.1570 Exit probability for efficacy, alt. = 0.4 0.0060 0.2110 0.3300 Exit probability for efficacy, alt. = 0.6 0.0630 0.5180 0.3060 Exit probability for efficacy, alt. = 0.8 0.1780 0.6710 0.1390 Exit probability for efficacy, alt. = 1 0.3850 0.5990 0.0160 Legend: alt.: alternative
Use getSimulationRates() as template.
getSimulationRates()
Implemented
Use
getSimulationRates()
as template.