issue with filtering of genes before DE analysis

saeyslab / multinichenetr

MultiNicheNet: a flexible framework for differential cell-cell communication analysis from multi-sample multi-condition single-cell transcriptomics data

GNU General Public License v3.0

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issue with filtering of genes before DE analysis #5

Closed browaeysrobin closed 2 years ago

browaeysrobin commented 2 years ago

muscat's default edgeR::filterByExprs is too stringent for pseudobulk data of single-cell cohort data.

own filtering solution currently fails for complex designs