The use of flow constraints is not mandatory. If signal implies flow and flow implies signal are False, there is no need to use flow. This can improve performance in big problems where the large stoichiometric matrix for flow is more a disadvantage than an advantage
The use of flow constraints is not mandatory. If signal implies flow and flow implies signal are False, there is no need to use flow. This can improve performance in big problems where the large stoichiometric matrix for flow is more a disadvantage than an advantage