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salesforce / progen

Official release of the ProGen models
BSD 3-Clause "New" or "Revised" License
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how to run log likelihood score script on a 2 chain protein? #5

Closed avilella closed 2 years ago

avilella commented 2 years ago

Is there a way to specify a 2 chain protein (e.g. an antibody Fv) as the input of the likelihood.py script? E.g. separating the two chains by a semi-colon or a colon or something like that? Thx in advance.

a-mad commented 2 years ago

specifying a linker (e.g. any combination of glycine-serine flexible linkers) between the two domains works well empirically

for your antibody use-case, i'd go with (GGGGS)x3

a-mad commented 2 years ago

@avilella can you close this issue, if it's satisfactory?