oncology is a broad therapeutic area - need to focus on sub-areas of oncology
solid tumor - how quickly and how significantly you can shrink the tumor
hematological - decrease/increase of parameter
PRO data - how can it be incorporated alongside traditional clinical data - e.g. quality of life as a differentiator when response rate is only non-inferior
spider/radar chart - choose a set of continuous/ordinal outcomes and animate change from baseline
short term and long term dynamics - quality of life
capture event or progression itself in the bar chart race -
think about using the solar system animation to visualize state change
radar chart for PRO? check out Doug's PRO data visualization
composite PRO data against tumor response data in a Gapminder-esque animated scatter plot over time
add view that aligns start of current response across all participants
add a control to align bars at start of current response
x-range would not change but x-domain would need to be split in two: time to current response on the left, duration of current response on the right... might be unintuitive
annotate durable response, e.g. draw a vertical line at 8 weeks indicating durability
add visit-level pauses at median study day of visit that overlays text describing the current level of response
Low priority
add a control to set animation speed
should not reset animation to beginning
add a control to set durable response duration
add a control to sort by duration of current response or by time to current response
add a control to align bars at end of time to any response
similarly x-range would not change but x-domain would need to be split in two: time to any response on the left, duration of current response on the right... might be unintuitive
add a control to set the upper limit of the x-axis to the current timepoint or the final timepoint
add an introductory, static explanatory screen - color coding, x-axis, y-axis - like a tutorial
add interactivity
click a bar to view the participant's details
click a bar to highlight that participant and their progression
Ideas
sync speed of animation with rate of change?
e.g. speed up between visit windows and slow down around visit windows
or have a shorter duration for timepoints without change and a longer duration for timepoints with change
longer bars are intuitive but how can we emphasize good outcomes over smaller time periods?
Bugs
response bars on the right side aren't transitioning
no transition between study and current response views
if we sort by time to progression we basically have a survival plot - just a matter of sorting the IDs by ascending time to progression - censored participants
can we highlight participants with specific treatments - NAD, IDT, etc.
incorporate subgroups in forest plot from paper - filtering or stratifying
add a subgroup control
it would be informative to support annotation of events-of-interest - skeletal-related events, hematologic improvement, etc.
Add sort by total duration as a survival curve view.
Add median duration of response - participants >median sorts upward, <median sorts downward.
This approach allows comparison of efficacy between arms.
Group participants by treatment group?
Add a benchmark or destination - durable response?
Rather than a continuous bar draw one bar segment per day that moves from the right and lands on the left - piling up toward durable response. Or just dropping down from above the bar into place.
Priorities
Let's not group by response type - PDs are going to happen and take focus away from the positive.
Add the overall survival curve view (transplants still at the top?).
Add the PFS view.
Add a sort and group control.
Update x-axis unit to months, say, or 28-day cycles.
Emphasize durability - brighten participants who have achieved durability, overlay a "finish line": x cycles. Make durability configurable.