I have Illumina reads for isolates from an evolution experiment but only have nanopore reads for the ancestral strain. It looks like the main differences between the evolved strains and the ancestor are SNPs but there might be some structural variation too e.g IS movement. Can I use Circlator to circularise the evolved strain assemblies using ancestral nanopore reads?
I have Illumina reads for isolates from an evolution experiment but only have nanopore reads for the ancestral strain. It looks like the main differences between the evolved strains and the ancestor are SNPs but there might be some structural variation too e.g IS movement. Can I use Circlator to circularise the evolved strain assemblies using ancestral nanopore reads?