sansomlab / cellhub

Python pipelines for large-scale multimodal single-cell data analysis on HPC clusters
MIT License
6 stars 2 forks source link

Sns add cellranger count #45

Closed snsansom closed 1 year ago

snsansom commented 1 year ago

This pull request replaces pipeline_cellranger_multi.py with pipeline_cellranger.py.

The new pipeline:

See the docs in pipeline_cellranger.py for a description of the required inputs.

It is important to allocate the cellranger jobs 8 cores and at least 64GB of memory (in the yaml file). Recommend to use 128GB memory whenever possible. Cellranger runs dramatically slower with less memory, see the plots here: https://support.10xgenomics.com/single-cell-gene-expression/software/overview/system-requirements.

With 8 cores and 128GB the individual cellranger jobs complete in ~2 hours on the BMRC cluster.