sars-cov-2-variants / lineage-proposals

Repository to propose and discuss lineages
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Multiple JN.1* branches with S:F456X : 4 Ongoing Unproposed Branches as 7/25 #1253

Closed xz-keg closed 2 months ago

xz-keg commented 10 months ago

It seems that S:F456L is very convergent in JN.1 now. (last complete update June 19)

Doublets and Singlets no longer tracking. Only track >=3 branches, or branches with seqs from multiple countries now.

Memorablea commented 5 months ago

image please see it:G4162A, T22928C, G26660T

xz-keg commented 5 months ago

image please see it:G4162A, T22928C, G26660T

That's branch 26 already proposed.

FedeGueli commented 5 months ago

Branch 83 by @DoropFan now 6 all very recent 5 with H445P and 1 with FLiRT.

Screenshot 2024-05-09 alle 18 21 00

https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice13_genome_test_22ce3_ce3600.json?c=gt-S_249&gmax=25384&gmin=21563&label=id:node_6964265

Suggested query for 445P: G22309C, C4456T,C9298T Suggested query for 346T: G22309C, C4456T,C9298T,G22599C

I suggest to propose it @aviczhl2 or @DoropFan once it reaches 10.

@aviczhl2 @DoropFan please propose it in the main Pango page : it is now 8 with 6 countries plus one unknown GBW sample seems very fast potentially

FedeGueli commented 5 months ago

Checking Branch 83 i found a similar unrelated variant that arose in England only three samples: JN.1.4 >>> T18453C > C27297T > S:L249F (G22309T), S:F456L (T22930A ) Query: G22309T ,T22930A,T3565C

Screenshot 2024-05-12 alle 23 54 29

https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_1ab27_139320.json?label=id:node_7096449

FedeGueli commented 5 months ago

Not sure if you want to track it here but there is another XDK +456L that emerged recently in Spain: (different from #1511 and #1467)

XDK (572I) > C22388T > S:F456L (T22928C) Query: C5314T, T22928C,C22388T Samples: 20

Screenshot 2024-05-13 alle 13 53 51

https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice2_genome_test_188d1_1fabb0.json?c=userOrOld&label=id:node_7023724

FedeGueli commented 5 months ago

branch 36 has now a flirt singlet, i suggest a revisited query: T22928C,C26753T,C18894T,T19092C to exclude some unrelated flirt sequences. with this query is 33

Screenshot 2024-05-13 alle 20 04 14

https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice12_genome_test_120f9_24d3e0.json?c=gt-S_346&label=id:node_6973750

FedeGueli commented 5 months ago

+1 FLirt Branch 55

xz-keg commented 5 months ago

Not sure if you want to track it here but there is another XDK +456L that emerged recently in Spain: (different from #1511 and #1467)

XDK (572I) > C22388T > S:F456L (T22928C) Query: C5314T, T22928C,C22388T Samples: 20 Screenshot 2024-05-13 alle 13 53 51 https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice2_genome_test_188d1_1fabb0.json?c=userOrOld&label=id:node_7023724

yeah I was tracking this one. Previously Spain only so not proposed, Now it also exports to USA.

FedeGueli commented 5 months ago

A22474G, G28456A,C10755T, T22928C JN.1.7+456L + orf9b:R58K now 4 from 2 unsure if worth adding or not at this point

xz-keg commented 5 months ago

Branch 54 designated JN.1.49.2 via https://github.com/cov-lineages/pango-designation/commit/3f31249f349fbcb4d67fd194fa23b1cc34e60316

FedeGueli commented 5 months ago

updated br.96 +1 > 3

FedeGueli commented 5 months ago

@aviczhl2 please propose branch 73 it has a FLiRT branch that topped 8 yesterday:

Screenshot 2024-05-17 alle 09 28 34

The FLiRT branch is tracked in #1089 as :

Branch 112: FLiRT ( originally spotted in Branch 73 of https://github.com/sars-cov-2-variants/lineage-proposals/issues/1253 by @aviczhl2 ) JN.1>C27110T>S:F456L(T22928C) >C3244T, A18432T> G29383A > S:R346T (G22599C), Query:C3244T, A18432T,G22599C Samples: 8 (Ireland, Scotland, California) ( 5 with S:M153I Query: C9169T, T12987C)

Last sample from ireland has S:T500N with S:M153I

FedeGueli commented 5 months ago

Branch 12 has now a growing FLiRT branch of 3 samples 2 countries tracked in #1089 as:

Branch 138 sublineage of Branch 12 of #1253 FLiRT ex singlet 72 JN.1.15 (S:A688V) > C19269 ,Orf3a:R122S (A25758T)> S:F456L (T22928C) > S:R346T (G22599C) Query: C23625T,G22599C,C19269T,T3565C Samples: 3 Spain, US

Worth proposing it too.

FedeGueli commented 5 months ago

Branch 83 by @DoropFan now designated JN.1.50 via https://github.com/cov-lineages/pango-designation/issues/2587

xz-keg commented 5 months ago

sub-branch of branch 45 designated JN.1.1.8.

xz-keg commented 5 months ago

Add branch 97-99

xz-keg commented 5 months ago

Add branch 100, a Canadian cluster

xz-keg commented 5 months ago

I just checked , 90%+ of branch 45 belongs to JN.1.1.8. Shall be a proper designation.

FedeGueli commented 5 months ago

I just checked , 90%+ of branch 45 belongs to JN.1.1.8. Shall be a proper designation.

Do you mean it is ok?

FedeGueli commented 5 months ago
  • C25566T

Add branch 97-99

Branch 99 is the one proposed in https://github.com/cov-lineages/pango-designation/issues/2589

FedeGueli commented 5 months ago

Branch 95 now 21 seems growing quite fast now

DailyCovidCases commented 5 months ago

Branch 10 is pretty much dead now: https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?nucMutations=T18453C%2CT22928C%2CC9979T&nextcladePangoLineage=JN.1.4*&

FedeGueli commented 5 months ago

Br 18 (JN.1.49) is now 44 with multiple FLiRT and FLiRI sublineages

FedeGueli commented 5 months ago

br.16 has been proposed in https://github.com/cov-lineages/pango-designation/issues/2595

DailyCovidCases commented 5 months ago

Branch 10 is likely dying off now: usher Screenshot (49)

FedeGueli commented 5 months ago

I m proposing branch 55 ( aka br.84 of 1089) is now 13 and well distributed in a vast area

FedeGueli commented 5 months ago

@aviczhl2 i m going to propose directly this new spanish branch of JN.1.30 + 456L +572I i think we missed it but seems interesting,

Screenshot 2024-05-20 alle 12 42 36

https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice3_genome_test_36e7f_b21640.json?label=id:node_7073772

wait wait it a XBB.1.16 from Chile misplaced here (EDITED)

proposed in https://github.com/cov-lineages/pango-designation/issues/2598

xz-keg commented 5 months ago

@aviczhl2 i m going to propose directly this new spanish branch of JN.1.30 + 456L +572I i think we missed it but seems interesting, Screenshot 2024-05-20 alle 12 42 36 https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice3_genome_test_36e7f_b21640.json?label=id:node_7073772

wait wait it a XBB.1.16 from Chile misplaced here (EDITED)

proposed in cov-lineages/pango-designation#2598

That's not a sub-branch of JN.1.30, the usher placement is wrong here. I suspect this being sub-branch of JN.1.16 so didn't listed.

FedeGueli commented 5 months ago

branch 30 now 32 seqs mostly from canadian clusters

FedeGueli commented 5 months ago

[Scartch:Br.62 now 45 27 with FLirt, after verifying the placement i would suggest to propose it]

Branch 62 is now under JN.1.16.1 close it please. ( i would not complicate further with masked nuc thing) https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/singleSubtreeAuspice_genome_test_35057_c768e0.json?f_userOrOld=uploaded%20sample&label=id:node_7135547

FedeGueli commented 5 months ago

Not sure if you want to track it here but there is another XDK +456L that emerged recently in Spain: (different from #1511 and #1467) XDK (572I) > C22388T > S:F456L (T22928C) Query: C5314T, T22928C,C22388T Samples: 20 test.gi.ucsc.edu/trash/ct/subtreeAuspice2_genome_test_188d1_1fabb0.json?c=userOrOld&label=id:node_7023724

yeah I was tracking this one. Previously Spain only so not proposed, Now it also exports to USA.

32 for this worth proposing i think.

FedeGueli commented 5 months ago

Br.51 now 58 worth proposing

FedeGueli commented 5 months ago

Br.52 now 55 worth proposing

FedeGueli commented 5 months ago

Br.58 now 54 worth proposing

FedeGueli commented 5 months ago

Br.12 proposed in https://github.com/cov-lineages/pango-designation/issues/2604

FedeGueli commented 5 months ago

Br.30 proposed in https://github.com/cov-lineages/pango-designation/issues/2605

FedeGueli commented 5 months ago

Br 21 proposed in https://github.com/cov-lineages/pango-designation/issues/2607

FedeGueli commented 5 months ago

Br 18 now proposed in https://github.com/cov-lineages/pango-designation/issues/2609

FedeGueli commented 5 months ago

Not sure if you want to track it here but there is another XDK +456L that emerged recently in Spain: (different from #1511 and #1467) XDK (572I) > C22388T > S:F456L (T22928C) Query: C5314T, T22928C,C22388T Samples: 20 test.gi.ucsc.edu/trash/ct/subtreeAuspice2_genome_test_188d1_1fabb0.json?c=userOrOld&label=id:node_7023724

yeah I was tracking this one. Previously Spain only so not proposed, Now it also exports to USA.

32 for this worth proposing i think.

37 now i m proposing it

FedeGueli commented 5 months ago

Br 36 now proposed in https://github.com/cov-lineages/pango-designation/issues/2613

FedeGueli commented 5 months ago

Br.24 now proposed in https://github.com/cov-lineages/pango-designation/issues/2612

FedeGueli commented 5 months ago

Br.52 (JN.1.4.2 with 185D 680F 456L) up to 58 worth proposing it https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_2d71c_441b50.json?label=id:node_7103772

Screenshot 2024-05-27 alle 10 23 27
xz-keg commented 5 months ago

Branch 34 designated JN.1.54.1 via https://github.com/cov-lineages/pango-designation/commit/d4897dae54782f87ceda609bc30252dcd22905c7 Branch 18 designated JN.1.29.1 Branch 52 designated LL.1 via https://github.com/cov-lineages/pango-designation/commit/891b587110a8c753bd224c51bae14168b8701eed Branch 32 designated JN.1.51.1 Branch 37 designated JN.1.18.3 Branch 81 designated JN.1.18.4

FedeGueli commented 5 months ago

Br.51 now at 68 worth proposing it

FedeGueli commented 5 months ago

Br.53 proposed in https://github.com/cov-lineages/pango-designation/issues/2621

FedeGueli commented 5 months ago

Br.100 now proposed in https://github.com/cov-lineages/pango-designation/issues/2620

FedeGueli commented 5 months ago

Br.51 now proposed in https://github.com/cov-lineages/pango-designation/issues/2622

FedeGueli commented 5 months ago

Branch 93 designated KR.2 via https://github.com/cov-lineages/pango-designation/commit/63b5972491744405195be9ae3fc53595b9f213ea

FedeGueli commented 5 months ago

Branch 87 designated KR.3 via https://github.com/cov-lineages/pango-designation/commit/358827b1a5b0c8a6307c210a062c28b74cae0354

FedeGueli commented 5 months ago

Branch 24 designated Jn.1.55.2
Branch 95 designtaed Jn.1.55.1 both via via https://github.com/cov-lineages/pango-designation/commit/9facdf971310a50205b17d386b060469f1610e49