KP.3.2 with ORF1b:Y1761H [nsp14_Y237H] and S:S477D [S>N477D] (43 seqs, Canada)

[NkRMnZr]

Defining Mutations: KP.3.2 > C29530A > C5407T > C17745T, T18748C(ORF1b:Y1761H) > A22991G(S:S477D, on top of G22992A/S:S477N), C25614T Query: C17745T, A22991G Earliest seq: 2024-05-28 (EPI_ISL_19199273, Ontario, Canada) Latest seq: 2024-06-03 (EPI_ISL_19199282, Ontario, Canada) Sampled Countries: Canada (10: ON)

Genomes:

for `lineages.csv` commit: ``` Canada/ON-PHL-202408936/2024 Canada/ON-PHL-202408938/2024 Canada/ON-PHL-202408939/2024 Canada/ON-PHL-202408940/2024 Canada/ON-PHL-202408941/2024 Canada/ON-PHL-202408942/2024 Canada/ON-PHL-202408943/2024 Canada/ON-PHL-202408945/2024 Canada/ON-PHL-202408946/2024 Canada/ON-PHL-202408947/2024 ``` epi_isl accessions: `EPI_ISL_19199273-19199282`

UShER:

Trivia:

• This branch changed B.1.1.529 basal S:S477N(G22992A) to S:S477D(A22991G) through 2-nuc mutations.
• It might just be some targeted cluster seqs from Canada, the accession numbers hinted that. Coincidence or not, there's also another sub-branch of KP.3.2.4 from England with this 2-step mutation.

[NkRMnZr]

closing this one, probably a targeted cluster; however there's another branch mentioned above from England developed something odd (C22506T/S:T315I, G23282C/S:D574H), though most seqs are not on gisaid yet.

[FedeGueli]

closing this one, probably a targeted cluster; however there's another branch mentioned above from England developed something odd (C22506T/S:T315I, G23282C/S:D574H), though most seqs are not on gisaid yet. ![image]

C22506T, G23282C 1 on Gisaid

[NkRMnZr]

43 now still in Ontario only, probably a cluster?

[FedeGueli]

yeah i think so!