KP.3.3 with Orf7b:I27V and Orf3a:W45C (574 seqs 16 countries )

[FedeGueli]

Hawaii is experiencing a surge in cases, with KP.3 at 30% of samples collected after May 15 it is very likely that it is the main driver of this new wave. About 1/3 of KP.3 samples belong to a local lineage with two mutations outside the spike : Orf7b:I27V, Orf3a:W45C. Even if unlikely this will turn to be other than founder effect it is worth checking if it will expand outside Hawaii Two samples have been collected in US airports by GBW in travellers from France and South Korea, so it is likely this lineage has originated elsewhere maybe in Philippines or Polinesia.

Defining mutations: KP.3.3>> orf7b:I26V (A27831G), Orf3a:W45C (G25527T) Query: A27831G,G25527T Samples:54 (Hawaii, US, Canada, Japan, France, South Korea) Tree:

https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_44525_2da2d0.json?label=id:node_7000250

IDs: EPI_ISL_19101713, EPI_ISL_19153993, EPI_ISL_19164085, EPI_ISL_19169331, EPI_ISL_19176013, EPI_ISL_19176060, EPI_ISL_19176077, EPI_ISL_19176089, EPI_ISL_19176096-19176097, EPI_ISL_19176104, EPI_ISL_19176117, EPI_ISL_19176122, EPI_ISL_19176236, EPI_ISL_19178146, EPI_ISL_19182967, EPI_ISL_19189030-19189031, EPI_ISL_19189387-19189388, EPI_ISL_19189406, EPI_ISL_19189421, EPI_ISL_19189442, EPI_ISL_19189452, EPI_ISL_19189608, EPI_ISL_19191625, EPI_ISL_19191829, EPI_ISL_19193282, EPI_ISL_19193340, EPI_ISL_19193388, EPI_ISL_19194098, EPI_ISL_19195948, EPI_ISL_19196556, EPI_ISL_19197304, EPI_ISL_19197414, EPI_ISL_19197548, EPI_ISL_19197564, EPI_ISL_19200405, EPI_ISL_19200425, EPI_ISL_19200428, EPI_ISL_19200432, EPI_ISL_19200434, EPI_ISL_19200450, EPI_ISL_19200454, EPI_ISL_19200492, EPI_ISL_19200494-19200495, EPI_ISL_19200516, EPI_ISL_19200518, EPI_ISL_19200530, EPI_ISL_19200541, EPI_ISL_19202350, EPI_ISL_19203445, EPI_ISL_19203965

[Mydtlwn]

@corneliusroemer

[FedeGueli]

At the end of June this is around 20% in Hawaii . It has been sampled in 5 States: US (5 states) , Japan (4 provinces), Canada (2 states), France and Israel.

[FedeGueli]

150 now, prevalence in Hawaii looks like growing further (while KP.3 prevalence is stable at 50% in June there)

[FedeGueli]

It seems going down where it emerged

[FedeGueli]

420

[FedeGueli]

This topped 479 , with a wide geographical ditribution expecially in the pacific area Hawaii, French Polinesia, Japan and then Oceania with also a GBW sample recently collected from a traveller from India!

ping @corneliusroemer

[FedeGueli]

539 new countries Hong Kong and Denmark: ping @corneliusroemer this sublineage has emerged as a local Hawaian lineage but it seems able to spread globally , maybe helped by tourism in the area of emergence

[FedeGueli]

574

[FedeGueli]

big but it cannot compete