sars-cov-2-variants / lineage-proposals

Repository to propose and discuss lineages
42 stars 2 forks source link

XEC: Potential KS.1.1/KP.3.3 recombinant(27 seqs, 7 countries) #1827

Closed Over-There-Is closed 1 month ago

Over-There-Is commented 1 month ago

Mutations based on JN.1: C18657T, C19716T, C21627A, T21738C, T22928C, C23039G, G24872T, C25006T, C28291A, G28884C The 5' donor could be from a pre-C6701T KS.1.1 branch with C18657T. Breakpoint: 21738\~22599 Query: C18657T, C19716T, C25006T

Earliest sequence: 06-24 Berlin, Germany EPI_ISL_19283881 Latest sequence: 07-19 Berlin, Germany EPI_ISL_19300184 Regions detected: Germany 11, France 1, Netherlands 1, South Korea 1, UK 1

https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_592af_f5e730.json?f_userOrOld=uploaded%20sample image

Sequences: EPI_ISL_19270230, EPI_ISL_19283843, EPI_ISL_19283881, EPI_ISL_19283891, EPI_ISL_19283905, EPI_ISL_19288354, EPI_ISL_19292873, EPI_ISL_19299882, EPI_ISL_19300184, EPI_ISL_19304941, EPI_ISL_19308953, EPI_ISL_19308959, EPI_ISL_19308971, EPI_ISL_19308982, EPI_ISL_19308990

aviczhl2 commented 1 month ago

So this is KP.3.3+T22N,F59S?

aviczhl2 commented 1 month ago

S:T22N is usually missed from sequencing. Use C19716T, G24872T, C25006T we can get an actual toll of 15, all 15 seqs have T21738C and really belong to this recomb.

image

Over-There-Is commented 1 month ago

S:22 seems getting affected by the insertion. image

JosetteSchoenma commented 1 month ago

+3 in today's upload from the Netherlands. The now 4 Dutch samples are from 4 separate regions.

FedeGueli commented 1 month ago

It seems fast.

ryhisner commented 1 month ago

+3 in today's upload from the Netherlands. The now 4 Dutch samples are from 4 separate regions.

Also two from Sweden, three from the United States (Virginia), and one from Spain uploaded today. That's some really fast geographic spread.

FedeGueli commented 1 month ago

Please propose it. Ping @corneliusroemer rapid designation needed

aviczhl2 commented 1 month ago

+2 GBW from Germany , 1 USA local and 1 from Sweden today.

FedeGueli commented 1 month ago

@Over-There-Is please propose it

Over-There-Is commented 1 month ago

Transferred to cov-lineages/pango-designation#2717.

FedeGueli commented 1 month ago

Designated XEC via https://github.com/cov-lineages/pango-designation/commit/c8b9d2ded49bf3d2870e94d1702046efeea8e533