MC.9 (KP.3.1.1 + Orf3a:K75N) with S:T638R (C>G) , 52 from >5 places >20% in Puerto Rico after September 20

[FedeGueli]

MC.9 is a sub-branch of KP.3.1.1 slighty faster than KP.3.1.1 baseline. S:T638R is a rare C>G mutation present in just 250 seqs from the start of the pandemic. Recently popped up three times on KP.3.1.1 backbone , the most interesting lienage is the MC.9 sub branch with it featuring also an Orf3a:R30H further mutation

Dadonaite and Bloom predicts it to reduce expression and escape, instead slighty improving binding on XBB.1.5 backbone

MC.9 >> G23611T > T5527C, Orf3a:R30H (G25481A) > S:T638R (C23475G) Query: C23475G,T5527C Samples: 12 Countries: 3 Mostly US, Canada, Ireland Tree:

https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_64cc_d240b0.json?label=id:node_7047076

[FedeGueli]

16 Puerto Rico

[FedeGueli]

18, Netherlands

[Over-There-Is]

23

[xz-keg]

34 now.

[FedeGueli]

34 now.

20% of last month samples from Portorico

[FedeGueli]

39, England

[FedeGueli]

42

[FedeGueli]

49

[FedeGueli]

@xz-keg maybe this deserves a proposal, it is not fast but emerged in an undersampled area and recent samples outside Canada and a rare mutation. What do you think? not urgent anyway