FL.10 saltation with ORF1a:G4178S, ORF1b:N1382S, S:K356T, S:T523N, ORF3a:D27N, ORF7b:N38I, N:K373N, N:D415E (14 seqs, Canada and USA)

[NkRMnZr]

Defining Mutations: FL.10 > C18888T > T11422C, G12797A(ORF1a:G4178S/nsp9_G38S), A17612G(ORF1b:N1382S/nsp13_N459S), A22629C(S:K356T), C23130A(S:T523N), G25471A(ORF3a:D27N), A27868T(ORF7b:N38I), G29392C(N:K373N), C29518A(N:D415E) Query: A22629C, C23130A, G25471A Earliest seq: 2023-06-10 (EPI_ISL_17821379, Alberta, Canada) Latest seq: 2023-07-20 (EPI_ISL_18055211, Ontario, Canada) Sampled Countries: Canada (4, Ontario/3, Alberta/1), US (1, Washington)

Genomes:

`EPI_ISL_17821379, EPI_ISL_17994047, EPI_ISL_18030530, EPI_ISL_18040062, EPI_ISL_18055211`

Saltation Profile:

mutations on neatest neighboring branch:

nuc unique  G12797A, A17612G, C23130A, G25471A, A27868T, G29392C, C29518A
nuc homoplasies T11422C, A22629C
ORF1ab  unique  G4178S, N5783S
S   unique  T523N
S   homoplasies K356T
ORF3a   unique  D27N
ORF7b   unique  N38I
N   unique  K373N
N   homoplasies D415E

details

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3502e_a4dee0.json?f_userOrOld=uploaded%20sample

[FedeGueli]

Thx good catch, @ryhisner could you see some treatment related pattern here?
And leaving mov aside, also that double C > A mutations seems interesting G12797A, A17612G, C23130A, G25471A, A27868T, G29392C, C29518A,T11422C, A22629C

[ryhisner]

Definitely not molnupiravir-related. 5/9 mutations on the saltation branch are transversions, which is much higher percentage than normal.

[FedeGueli]

One more from Canada, Alberta

[NkRMnZr]

Tracking updates:

08-05, 1 from Alberta: EPI_ISL_18062502 08-18, 2 from Canada (Saskatchewan and Ontario): EPI_ISL_18105084, EPI_ISL_18111070 08-22, 2 seqs from USA (Iowa and Washington) 08-26, 4 seqs from Alberta

[NkRMnZr]

08-22, 2 seqs from USA: 1 from Iowa: EPI_ISL_18115924 1 from Washington: EPI_ISL_18121166

[NkRMnZr]

08-26, 4 seqs from Alberta: EPI_ISL_18129671, EPI_ISL_18129682, EPI_ISL_18129690, EPI_ISL_18129707

[FedeGueli]

Please propose it.

[NkRMnZr]

transferred to cov-lineages/pango-designation#2220

[FedeGueli]

https://github.com/cov-lineages/pango-designation/commit/a397154801c054bea353ab455553242efd4bd0aa

designated FL.10.2