Feature request: add option to perform gene burden analysis

scholl-lab / vcf-filtering

A collection of scripts for filtering annotated variant call format files

MIT License

3 stars 1 forks source link

Feature request: add option to perform gene burden analysis #24

Open berntpopp opened 3 months ago

berntpopp commented 3 months ago

This will require subsetting into cohorts and applying a model/ statisical test.

berntpopp commented 3 months ago

also see https://github.com/halbritter-lab/stoneformers-multisample-vcf/issues/4

berntpopp commented 3 months ago

Relates to #23

Also add counts for cohort sizes (control vs. affected)

berntpopp commented 3 months ago

I think this should be for now a simple test like Fishers exact probands vs. controls with FDR correction of the values just on the merged variant counts.