> [Bug] `rank_genes_groups` after `normalize_pearson_residuals`

scverse / scanpy

Single-cell analysis in Python. Scales to >1M cells.

https://scanpy.readthedocs.io

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> [Bug] `rank_genes_groups` after `normalize_pearson_residuals` #2501

Open Starlitnightly opened 1 year ago

Starlitnightly commented 1 year ago

Hi, @jlause

There's a issue when using normalize_pearson_residuals, it seems that we can't calculated the log2foldchange in rank_genes_groups will be failed. That's because np.expm1 can't restore the adata.X after normalize_pearson_residuals. Could you solve this issue that completed the downstream currently?

kcArtemis commented 10 months ago

I would like to work on this issue.