Flaws with current approaches for normalization, PCA, and feature selection?

scverse / scanpy

Single-cell analysis in Python. Scales to >1M cells.

https://scanpy.readthedocs.io

BSD 3-Clause "New" or "Revised" License

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Flaws with current approaches for normalization, PCA, and feature selection? #531

Open brennerUT opened 5 years ago

brennerUT commented 5 years ago

I just saw this biorxiv manuscript and I was wondering if there are any ways to easily incorporate multinomial methods in scanpy Feature Selection and Dimension Reduction for Single Cell RNA-Seq based on a Multinomial Model

falexwolf commented 5 years ago

We're very happy to consider PRs around engineering representations around NB or multinomial methods. But we have to admit that we're not currently working on this.