Alleloscope is a method for allele-specific copy number estimation that can be applied to single cell DNA and ATAC sequencing data (separately or in combination). Allele-specific estimation allows for the more accurate delineation of copy number states and the detection of subclonal copy-neutral loss-of-heterozygosity and mirrored CNA events. On scATAC-seq data, Alleloscope allows integrative multi-omic analysis of allele-specific copy number and chromatin accessibility for the same cell.
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Question about generation of snp by cell matrics #14
I have a question regarding to how to prepare the snp by cell matrics, in your example, genotype vcf files are generated from single cells, where the ref/alt matrics could be told as I assume. I an not quite follow how the matrics could be generated, could you explain this in more details?
Hi,
I have a question regarding to how to prepare the snp by cell matrics, in your example, genotype vcf files are generated from single cells, where the ref/alt matrics could be told as I assume. I an not quite follow how the matrics could be generated, could you explain this in more details?
Many thanks!