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sfu-compbio / sinvict

SiNVICT: Ultra-Sensitive Detection of Single Nucleotide Variants and Indels in Circulating Tumour DNA
http://sfu-compbio.github.io/sinvict
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Can SiNVICT call the somatic mutation? #4

Closed Tinalxt closed 7 years ago

Tinalxt commented 7 years ago

Hi~ I wonder if SiNVICT can call the somatic mutation? Such as a pair of tumor-nomal sample.

MIAOKUI commented 7 years ago

I also have this question

ckockan commented 7 years ago

Yes, that is possible. You need to run SiNVICT separately on the tumor and normal sample. Afterwards, you should subtract the mutations which were also detected in the normal sample from the set of variants called in the tumor sample.