Redesign of hybrid alignment system

sheynkman-lab / biosurfer

"Surf" the biological network, from genome to transcriptome to proteome and back to gain insights into human disease biology.

MIT License

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Closed jsaquing closed 2 years ago

jsaquing commented 2 years ago

Redesigning the hybrid alignment system to be more comprehensive:

All transcript-level differences between isoforms are identified
All protein sequence differences between isoforms can be traced back to underlying transcript-level events (i.e., alt splicing, alt TSS, and APA)
Transcript-level events are represented as their own objects, obviating the need for the annotation system